Antiviral Bafilomycins from a Feces-Inhabiting Streptomyces sp.

被引:23
作者
Xie, Xi [1 ]
Lu, Shengsheng [1 ]
Pan, Xiaoyan [2 ]
Zou, Min [1 ]
Li, Fangfang [3 ]
Lin, Haixing [1 ]
Hu, Jianan [1 ]
Fan, Sheng [1 ]
He, Jian [1 ]
机构
[1] Southern Med Univ, Sch Pharmaceut Sci, Grp Peptides & Nat Prod Res, Guangzhou 510515, Peoples R China
[2] Chinese Acad Sci, Ctr Biosafety Megasci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China
[3] China Natl Analyt Ctr, Guangdong Prov Key Lab Emergency Test Dangerous C, Guangzhou 510070, Peoples R China
来源
JOURNAL OF NATURAL PRODUCTS | 2021年 / 84卷 / 02期
基金
中国国家自然科学基金;
关键词
VIRUS ENTRY; MACROLIDE; IDENTIFICATION; INHIBITOR; ATPASES;
D O I
10.1021/acs.jnatprod.0c01243
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
A new bafilomycin derivative (1) and another seven known bafilomycins (2-8) were isolated from feces-derived Streptomyces sp. HTL16. The structure of 1 was elucidated by 1D and 2D NMR spectroscopic analysis. Biological testing demonstrated that these bafilomycins exhibited potent antiviral activities against the influenza A and SARS-CoV-2 viruses, with IC50 values in the nanomolar range, by inhibiting the activity of endosomal ATP-driven proton pumps.
引用
收藏
页码:537 / 543
页数:7
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