Antiviral Bafilomycins from a Feces-Inhabiting Streptomyces sp.

被引：23

作者：

Xie, Xi ^{[1
]}

Lu, Shengsheng ^{[1
]}

Pan, Xiaoyan ^{[2
]}

Zou, Min ^{[1
]}

Li, Fangfang ^{[3
]}

Lin, Haixing ^{[1
]}

Hu, Jianan ^{[1
]}

Fan, Sheng ^{[1
]}

He, Jian ^{[1
]}

机构：

[1] Southern Med Univ, Sch Pharmaceut Sci, Grp Peptides & Nat Prod Res, Guangzhou 510515, Peoples R China

[2] Chinese Acad Sci, Ctr Biosafety Megasci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China

[3] China Natl Analyt Ctr, Guangdong Prov Key Lab Emergency Test Dangerous C, Guangzhou 510070, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2021年 / 84卷 / 02期

基金：

中国国家自然科学基金;

关键词：

VIRUS ENTRY; MACROLIDE; IDENTIFICATION; INHIBITOR; ATPASES;

D O I：

10.1021/acs.jnatprod.0c01243

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new bafilomycin derivative (1) and another seven known bafilomycins (2-8) were isolated from feces-derived Streptomyces sp. HTL16. The structure of 1 was elucidated by 1D and 2D NMR spectroscopic analysis. Biological testing demonstrated that these bafilomycins exhibited potent antiviral activities against the influenza A and SARS-CoV-2 viruses, with IC50 values in the nanomolar range, by inhibiting the activity of endosomal ATP-driven proton pumps.

引用

页码：537 / 543

页数：7

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Lin, Dongguo ;

Luo, Yinzhu ;

Yang, Guang ;

Li, Fangfang ;

Xie, Xiangkun ;

Chen, Daiwei ;

He, Lifang ;

Wang, Jingyu ;

Ye, Chunfeng ;

Lu, Shengsheng ;

Lv, Lin ;

Liu, Shuwen ;

He, Jian .

BIOCHEMICAL PHARMACOLOGY, 2017, 144 :35-51

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