IFN-α and IFN-β: A link between immune memory and chronic inflammation

被引：115
|
作者：
Akbar, AN
Lord, JM
Salmon, M
机构：
[1] UCL Royal Free & Univ Coll Med Sch, Dept Clin Immunol, London NW3 2QG, England
[2] Univ Birmingham, MRC, Ctr Immunoregulat, Dept Immunol, Birmingham B15 2TT, W Midlands, England
[3] Univ Birmingham, MRC, Ctr Immunoregulat, Dept Rheumatol, Birmingham B15 2TT, W Midlands, England
来源：
IMMUNOLOGY TODAY | 2000年 / 21卷 / 07期
关键词：
D O I：
10.1016/S0167-5699(00)01652-2
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The majority of expanded T cells generated during an immune response are cleaned by apoptosis. Prevention of death in some activated T cells enables the persistence of a memory T-cell pool. Here, observations that IFN-alpha and IFN-beta inhibit activated T-cell apoptosis are described. Although this enables memory T cells to persist without antigen, excessive IFN-alpha ol IFN-gamma secretion might lead to chronic inflammation.
引用
收藏
页码：337 / +
页数：7
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