The diagnostic value of FNDC5/Irisin in Renal Cell Cancer

被引：0
|
作者：
Altay, Diler Us [1 ]
Keha, Esref Edip [2 ]
Karaguzel, Ersagun [3 ]
Mentese, Ahmet [2 ]
Yaman, Serap Ozer [2 ]
Alver, Ahmet [2 ]
机构：
[1] Ordu Univ, Ulubey Vocat Sch, Dept Chem & Chem Proc Technol, Lab Technol Program, Ordu, Turkey
[2] Karadeniz Tech Univ, Fac Med, Dept Med Biochem, Trabzon, Turkey
[3] Karadeniz Tech Univ, Fac Med, Dept Urol, Trabzon, Turkey
来源：
INTERNATIONAL BRAZ J UROL | 2018年 / 44卷 / 04期
关键词：
Carcinoma; Renal Cell; FNDC5; protein; rat [Supplementary Concept; Urologic Neoplasms; IRISIN; PROLIFERATION; EXPRESSION; PLASMA; FNDC5;
D O I：
10.1590/S1677-5538.IBJU.2017.0404
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Purposes: The aim of this study was to determine the diagnostic significance of fibronectin type III domain containing protein 5 (FNDC5)/Irisin levels in the sera of patients with renal cell cancer. Materials and Methods: In the study, 48 individuals were evaluated. The patient group included 23 subjects diagnosed with renal tumor, and the control group of 25 healthy individuals. Patients diagnosed with renal tumor received surgical treatment consisting of radical or partial nephrectomy. Blood specimens were collected and serum FNDC5/Irisin and carcinoembryonic antigen (CEA) levels were determined using enzymelinked immunosorbent assay (ELISA). Results: FNDC5/irisin and CEA levels in renal cancer patients were significantly higher compared with the control group (p=0.0001, p=0.009, respectively). Also, FNDC5 levels was more sensitive and specific than CEA levels. The best cut-off points for FNDC5/irisin were > 105pg/mL and CEA were > 2.67ng/mL for renal cancer. Conclusions: FNDC5/Irisin may be used as a diagnostic biomarker for renal cancer.
引用
收藏
页码：734 / 739
页数：6
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