STRUCTURAL BIOLOGY When four become one

被引：3

作者：

Craigie, Robert ^{[1
]}

机构：

[1] NIDDKD, Mol Biol Lab, NIH, Bethesda, MD 20892 USA

来源：

NATURE | 2010年 / 464卷 / 7286期

关键词：

CATALYTIC DOMAIN; HIV-1; INTEGRASE;

D O I：

10.1038/464167a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Every machine is made of parts. But, as the new structure of the HIV integrase enzyme in complex with viral DNA shows, one could not have predicted from the individual parts just how this machine works.

引用

页码：167 / 168

页数：2

共 7 条

[1] HIGH-RESOLUTION STRUCTURE OF THE CATALYTIC DOMAIN OF AVIAN-SARCOMA VIRUS INTEGRASE [J].

BUJACZ, G ;

JASKOLSKI, M ;

ALEXANDRATOS, J ;

WLODAWER, A ;

MERKEL, G ;

KATZ, RA ;

SKALKA, AM .

JOURNAL OF MOLECULAR BIOLOGY, 1995, 253 (02) :333-346

[2] Structure and function of HIV-1 integrase [J].

Chiu, TK ;

Davies, DR .

CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2004, 4 (09) :965-977

[3] Three-dimensional structure of the Tn5 synaptic complex transposition intermediate [J].

Davies, DR ;

Goryshin, IY ;

Reznikoff, WS ;

Rayment, I .

SCIENCE, 2000, 289 (5476) :77-85

[4] CRYSTAL-STRUCTURE OF THE CATALYTIC DOMAIN OF HIV-1 INTEGRASE - SIMILARITY TO OTHER POLYNUCLEOTIDYL TRANSFERASES [J].

DYDA, F ;

HICKMAN, AB ;

JENKINS, TM ;

ENGELMAN, A ;

CRAIGIE, R ;

DAVIES, DR .

SCIENCE, 1994, 266 (5193) :1981-1986

[5] Retroviral intasome assembly and inhibition of DNA strand transfer [J].

Hare, Stephen ;

Gupta, Saumya Shree ;

Valkov, Eugene ;

Engelman, Alan ;

Cherepanov, Peter .

NATURE, 2010, 464 (7286) :232-U108

[6] Retroviral DNA integration: reaction pathway and critical intermediates [J].

Li, M ;

Mizuuchi, M ;

Burke, TR ;

Craigie, R .

EMBO JOURNAL, 2006, 25 (06) :1295-1304

[7] Retroviral integrases and their cousins [J].

Rice, P ;

Craigie, R ;

Davies, DR .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1996, 6 (01) :76-83

← 1 →