Antagonism between Antiviral Signaling and Glycolysis

被引：13

作者：

Chauhan, Anoop Singh ^{[1
,2
]}

Zhuang, Li ^{[1
]}

Gan, Boyi ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Expt Radiat Oncol, Houston, TX 77030 USA

[2] Univ Birmingham, Inst Canc & Genom Sci, Birmingham B17 2TT, W Midlands, England

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2019年 / 30卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.tem.2019.07.010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

RIG-I-like receptor (RLR)-mediated interferon production is critical for antiviral responses. A recent study (Zhang et al., Cell, 2019) uncovered a reciprocal inhibition between RLR signaling and glycolysis: lactate produced by glycolysis inhibits RLR signaling by binding to RLR signaling component mitochondrial antiviral-signaling (MAVS), whereas RLR activation suppresses glycolysis through inhibiting glycolysis enzyme hexokinase.

引用

页码：571 / 573

页数：4

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