Recent developments in the pharmacological treatment and prevention of corneal graft rejection

被引：6

作者：

Banerjee, S ^{[1
]}

Dick, AD ^{[1
]}

机构：

[1] Univ Bristol, Sch Med Sci, Div Ophthalmol, Bristol BS8 1TD, Avon, England

来源：

EXPERT OPINION ON INVESTIGATIONAL DRUGS | 2003年 / 12卷 / 01期

关键词：

corneal transplantation; corticosteroids; cyclosporin A; immunosuppressants; mAb therapies; mycophenolate mofetil; tacrolimus;

D O I：

10.1517/13543784.12.1.29

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

At present, given the high initial success rate of corneal transplantation (although late survival is poor), immunosuppression is often reserved for 'high-risk' patients. Despite immune privilege, corneal graft rejection remains the leading cause of corneal allograft failure. Interpreting the limited and also restricted design of most trials, immunosuppressive therapy has not enjoyed the success seen in solid organ grafts. This review discusses the limited data available whilst proposing newer therapies that have developed as a result of our increased understanding of the immunobiology of corneal graft rejection.

引用

页码：29 / 37

页数：9

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[41] Topical Cyclosporin A in the treatment of acute graft rejection: a randomized controlled trial [J].

Poon, Alexander ;

Constantinou, Marios ;

Lamoureux, Ecosse ;

Taylor, Hugh R. .

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 2008, 36 (05) :415-421

[42] Mycophenolate mofetil (MMF) in heart transplantation: Rejection prevention and treatment [J].

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CLINICAL TRANSPLANTATION, 1996, 10 (01) :136-139

[43] Effectiveness of Topical Immunosuppressants in Prevention and Treatment of Rejection in Face Allotransplantation [J].

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[44] PREVENTION OF CORNEAL ALLOGRAFT-REJECTION IN RATS TREATED WITH SUBCONJUNCTIVAL INJECTIONS OF LIPOSOMES CONTAINING DICHLOROMETHYLENE DIPHOSPHONATE [J].

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INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1994, 35 (09) :3505-3515

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[47] Local and Systemic Injections of Human Cord Blood Myeloid-Derived Suppressor Cells to Prevent Graft Rejection in Corneal Transplantation [J].

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[50] Inhibition of murine corneal allograft rejection by treatment with antibodies to CD80 and CD86 [J].

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Kamiya, K ;

Kaji, Y ;

Oshika, T ;

Amano, S ;

Yamagami, S ;

Tsuru, T ;

Tanaka, S ;

Matsuda, H ;

Yagita, H ;

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