Comparing Abbott m2000 RealTime HIV test and Roche COBAS Ampliprep/COBAS Taqman HIV test, v2.0 in treated HIV-1 B and non-B subjects with low viraemia

被引：6

作者：

Margariti, Apostolia ^{[1
]}

Chatzidimitriou, Dimitrios ^{[1
]}

Metallidis, Simeon ^{[2
]}

Pilalas, Dimitrios ^{[2
]}

Kourelis, Andreas ^{[1
]}

Papadimitriou, Evangelia ^{[1
]}

Haidich, Anna-Bettina ^{[3
]}

Malisiovas, Nicolaos ^{[1
]}

Skoura, Lemonia ^{[1
]}

机构：

[1] Aristotle Univ Thessaloniki, Sch Med, Dept Microbiol, Natl AIDS Reference Ctr Northern Greece, GR-54006 Thessaloniki, Greece

[2] Aristotle Univ Thessaloniki, Sch Med, Div Infect Dis, Dept Internal Med 1, GR-54006 Thessaloniki, Greece

[3] Aristotle Univ Thessaloniki, Sch Med, Dept Hyg & Epidemiol, GR-54006 Thessaloniki, Greece

来源：

JOURNAL OF MEDICAL VIROLOGY | 2016年 / 88卷 / 04期

关键词：

viral load; real time PCR; HIV subtype; agreement study; LOW-LEVEL VIREMIA; VIRAL LOAD; 50; COPIES/ML; ASSAYS; RNA; AGREEMENT;

D O I：

10.1002/jmv.24369

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Viral load testing is a valuable tool in HIV clinical care and research. Discrepancies among diverse viral load assays, especially with regard to non-B HIV-1 subtypes have been reported. Our study aimed to explore the impact of HIV subtype (B versus non-B) on the agreement between CAP/CTM, v2.0 and m2000 RealTime in treated HIV patients, focusing on low viral loads (<200copies/ml). Our findings indicate that there is a significant difference in the performance of the compared assays in the low-viremic range and non-B subtypes, suggesting that a single assay should be used for follow-up. J. Med. Virol. 88:724-727, 2016. (c) 2015 Wiley Periodicals, Inc.

引用

页码：724 / 727

页数：4

共 22 条

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