Synthesis of Folate-Modified, Polyethylene Glycol-Functionalized Gold Nanoparticles for Targeted Drug Delivery

被引：22
|
作者：
Asadishad, B. [2 ]
Vosoughi, M. [2 ,3 ]
Alamzadeh, I. [1 ,2 ]
Tavakoli, A. [2 ]
机构：
[1] Sharif Univ Technol, Biochem & Bioenvironm Res Ctr, Tehran 113656891, Iran
[2] Sharif Univ Technol, Dept Chem & Petr Engn, Tehran 113656891, Iran
[3] Sharif Univ Technol, Inst Nanosci, Tehran 113656891, Iran
来源：
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY | 2010年 / 31卷 / 04期
关键词：
Doxorubicin; folic acid; gold nanoparticles; lysine; polyethylene glycol (peg); MAGNETITE NANOPARTICLES; DOXORUBICIN; RELEASE; CANCER; CELLS; CONJUGATE; COPOLYMER; MICELLES; THERAPY; POLYMER;
D O I：
10.1080/01932690903213113
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The chemical synthesis and in vitro drug delivery response of folate-modified, polyethylene glycol-functionalized gold nanoparticles were studied. Lysine-capped gold nanoparticles were first prepared. Subsequently, the widely used anticancer agent doxorubicin (DOX) was successfully attached to the surface of folate-modified, polyethylene glycol-functionalized gold nanoparticles. Fourier transform infrared spectroscopy (FTIR) and transmission electron microscopy (TEM) were used to confirm the functionalization and conjugation steps in the chemical synthesis. The DOX-loading efficiency determined by UV-vis spectrometer was 80%. Drug release experiments displayed a controlled-release behavior that most of the conjugated doxorubicin was released within the first 12 hours.
引用
收藏
页码：492 / 500
页数：9
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