Enzymatic alkoxycarbonylation reactions on the intermediate in the synthesis of (-)-paroxetine, trans-N-benzyloxycarbonyl-4-(4′-fluorophenyl)-3-hydroxymethyl- piperidine

被引：13
作者：
de Gonzalo, G
Brieva, R
Sánchez, VM
Bayod, M
Gotor, V [1 ]
机构：
[1] Univ Oviedo, Fac Quim, Dept Quim Organ & Inorgan, E-33071 Oviedo, Spain
[2] Astur Pharma SA, Poligono Ind Silvota, Llanera 33192, Spain
来源：
TETRAHEDRON-ASYMMETRY | 2003年 / 14卷 / 12期
关键词：
D O I：
10.1016/S0957-4166(03)00311-2
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Several enzymatic alkoxycarbonylation processes are evaluated for the resolution of trans-N-benzyloxycarbonyl-4-(4'-fluorophenyl)-3-hydroxymethylpiperidine, a chiral intermediate in the synthesis of (-)-paroxetine. Candida antarctica lipase B (CAL-B) catalyzes the enzymatic alkoxycarbonylation with diallylcarbonate with high enantioselectivity. (C) 2003 Elsevier Science Ltd. All rights reserved.
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收藏
页码：1725 / 1731
页数：7
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