The biological basis of antipsychotic response in schizophrenia

被引：38

作者：

Stone, James M. ^{[1
]}

Raffin, Marie ^{[1
]}

Morrison, Paul ^{[1
]}

McGuire, Philip K. ^{[1
]}

机构：

[1] Kings Coll London, Inst Psychiat, London SE5 8AF, England

来源：

JOURNAL OF PSYCHOPHARMACOLOGY | 2010年 / 24卷 / 07期

关键词：

schizophrenia; antipsychotic; non-responders; dopamine; glutamate; serotonin; PLASMA HOMOVANILLIC-ACID; CATECHOL-O-METHYLTRANSFERASE; DEXAMETHASONE SUPPRESSION TEST; TREATMENT-RESISTANT SCHIZOPHRENIA; DOPAMINE-D-2 RECEPTOR GENE; PHOTON-EMISSION-TOMOGRAPHY; HALOPERIDOL TREATMENT RESPONSE; CLOZAPINE TREATMENT RESPONSE; NEGATIVE SYMPTOM RESPONSE; EXON-III POLYMORPHISM;

D O I：

10.1177/0269881109106959

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Schizophrenia is a severe mental illness affecting approximately 1% of the population worldwide. Antipsychotic drugs are effective in symptom control in up to two-thirds of patients, but in at least one-third of patients the response is poor. The reason for this is not clear, but one possibility is that good and poor responders have different neurochemical pathologies, and may therefore benefit from different treatment approaches. In this selective review we summarise research findings investigating the biological differences between patients with schizophrenia who show a good or a poor response to treatment with antipsychotic drugs.

引用

页码：953 / 964

页数：12

共 169 条

[1] Increased baseline occupancy of D2 receptors by dopamine in schizophrenia [J].

Abi-Dargham, A ;

Rodenhiser, J ;

Printz, D ;

Zea-Ponce, Y ;

Gil, R ;

Kegeles, LS ;

Weiss, R ;

Cooper, TB ;

Mann, JJ ;

Van Heertum, RL ;

Gorman, JM ;

Laruelle, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (14) :8104-8109

[2] Prefrontal DA transmission at D1 receptors and the pathology of schizophrenia [J].

Abi-Dargham, A ;

Moore, H .

NEUROSCIENTIST, 2003, 9 (05) :404-416

[3] Dopamine receptor D3 genotype association with greater acute positive symptom remission with olanzapine therapy in predominately caucasian patients with chronic schizophrenia or schizoaffective [J].

Adams, David H. ;

Close, Sandra ;

Farmen, Mark ;

Downing, AnnCatherine M. ;

Breier, Alan ;

Houston, John P. .

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL, 2008, 23 (04) :267-274

[4] DEPRESSION DEXAMETHASONE NONSUPPRESSION AND NEGATIVE SYMPTOMS IN SCHIZOPHRENIA [J].

ADDINGTON, D ;

ADDINGTON, J .

CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE, 1990, 35 (05) :430-433

[5] Striatal vs extrastriatal dopamine D2 receptors in antipsychotic response -: A double-blind PET study in schizophrenia [J].

Agid, Ofer ;

Mamo, David ;

Ginovart, Nathalie ;

Vitcu, Irina ;

Wilson, Alan A. ;

Zipursky, Robert B. ;

Kapur, Shitij .

NEUROPSYCHOPHARMACOLOGY, 2007, 32 (06) :1209-1215

[6] Gene polymorphism influencing treatment response in psychotic patients in a naturalistic setting [J].

Alenius, Malin ;

Wadelius, Mia ;

Dahl, Marja-Liisa ;

Hartvig, Per ;

Lindstrom, Leif ;

Hammarlund-Udenaes, Margareta .

JOURNAL OF PSYCHIATRIC RESEARCH, 2008, 42 (11) :884-893

[7] RELATIONSHIPS BETWEEN CLINICAL EFFECTS AND MONOAMINE METABOLITES AND AMINO-ACIDS IN SULPIRIDE-TREATED SCHIZOPHRENIC-PATIENTS [J].

ALFREDSSON, G ;

WIESEL, FA .

PSYCHOPHARMACOLOGY, 1990, 101 (03) :324-331

[8] Schizophrenia: From genes to phenes to disease [J].

Allan C.L. ;

Cardno A.G. ;

McGuffin P. .

Current Psychiatry Reports, 2008, 10 (4) :339-343

[9] ASSESSMENT OF THE CENTRAL DOPAMINERGIC INDEX OF PLASMA HVA IN SCHIZOPHRENIA [J].

AMIN, F ;

DAVIDSON, M ;

KAHN, RS ;

SCHMEIDLER, J ;

STERN, R ;

KNOTT, PJ ;

APTER, S .

SCHIZOPHRENIA BULLETIN, 1995, 21 (01) :53-66

[10] The relationship of clozapine and haloperidol treatment response to prefrontal, hippocampal, and caudate brain volumes [J].

Arango, C ;

Breier, A ;

McMahon, R ;

Carpenter, WT ;

Buchanan, RW .

AMERICAN JOURNAL OF PSYCHIATRY, 2003, 160 (08) :1421-1427

← 1 2 3 4 5 6 7 8 9 10 →