Platelet-derived Extracellular Vesicles: An Emerging Therapeutic Approach

被引：131
作者：
Tao, Shi-Cong [1 ]
Guo, Shang-Chun [2 ]
Zhang, Chang-Qing [1 ,2 ]
机构：
[1] Shanghai Jiao Tong Univ, Dept Orthoped Surg, Affiliated Peoples Hosp 6, 600 Yishan Rd, Shanghai 200233, Peoples R China
[2] Shanghai Jiao Tong Univ, Inst Microsurg Extrem, Affiliated Peoples Hosp 6, 600 Yishan Rd, Shanghai 200233, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2017年 / 13卷 / 07期
基金：
中国国家自然科学基金;
关键词：
extracellular vesicle; micro-vesicle; exosome; platelet; regenerative medicine; platelet-rich plasma; MESENCHYMAL STEM-CELLS; RICH PLASMA; FEMORAL-HEAD; ACTIVATED PLATELETS; EXOSOMES; MICROPARTICLES; CANCER; MICROVESICLES; PROTEIN; INFLAMMATION;
D O I：
10.7150/ijbs.19776
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Extracellular vesicles (EVs) are a newly-discovered way by which cells communicate with their neighbors, as well as transporting cargos which once were considered to be limited by membrane barriers, including membrane proteins, cytosolic proteins and RNA. The discovery of platelet-derived EVs (P-EVs), the most abundant EVs in human blood, has been a very tortuous process. At first, P-EVs were identified as nothing but 'platelet dust', and subsequent research did not progress smoothly because of the limited research techniques to study EVs. Following leaps and bounds of technical progress in studying EVs, more and more attractive features of P-EVs were revealed and they began to be further researched. The aim of this review is to present the latest knowledge about the role of P-EVs in tissue repair and tumor progression. The potential mechanism of P-EVs is emphasized. Then the limitations of the present study and future research directions are discussed.
引用
收藏
页码：828 / 834
页数：7
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