Numerical simulation of electroosmotic flow

被引：450

作者：

Patankar, NA ^{[1
]}

Hu, HH ^{[1
]}

机构：

[1] Drexel Univ, Dept Mech Engn & Appl Mech, Philadelphia, PA 19104 USA

来源：

ANALYTICAL CHEMISTRY | 1998年 / 70卷 / 09期

关键词：

D O I：

10.1021/ac970846u

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We have developed a numerical scheme to simulate electroosmotic flows in complicated geometries. We studied the electroosmotic injection characteristics of a cross-channel device for capillary electrophoresis. We found that the desired rectangular shape of the sample plug at be intersection of the cross-channel can be obtained when the injection is carried out at high electric field intensities. The shape of the sample plug can also be controlled by applying an electric potential or a pressure at the side reservoirs. Flow induced from the side channels into the injection channel squeezes the streamlines at the intersection, thus giving a less distorted sample plug. Results of our simulations agree qualitatively with experimental observations.

引用

页码：1870 / 1881

页数：12

共 18 条

[1] ON THE MATHEMATICAL-MODEL OF CAPILLARY ELECTROPHORESIS [J].

ANDREEV, VP ;

LISIN, EE .

CHROMATOGRAPHIA, 1993, 37 (3-4) :202-210

[2] A NOVEL-APPROACH TO ION SEPARATIONS IN SOLUTION - SYNCHRONIZED CYCLIC CAPILLARY ELECTROPHORESIS (SCCE) [J].

BURGGRAF, N ;

MANZ, A ;

VERPOORTE, E ;

EFFENHAUSER, CS ;

WIDMER, HM ;

DEROOIJ, NF .

SENSORS AND ACTUATORS B-CHEMICAL, 1994, 20 (2-3) :103-110

[3] FLOW COUNTERBALANCED CAPILLARY ELECTROPHORESIS [J].

CULBERTSON, CT ;

JORGENSON, JW .

ANALYTICAL CHEMISTRY, 1994, 66 (07) :955-962

[4] HIGH-SPEED SEPARATION OF ANTISENSE OLIGONUCLEOTIDES ON A MICROMACHINED CAPILLARY ELECTROPHORESIS DEVICE [J].

EFFENHAUSER, CS ;

PAULUS, A ;

MANZ, A ;

WIDMER, HM .

ANALYTICAL CHEMISTRY, 1994, 66 (18) :2949-2953

[5] MICROMACHINING OF CAPILLARY ELECTROPHORESIS INJECTORS AND SEPARATORS ON GLASS CHIPS AND EVALUATION OF FLOW AT CAPILLARY INTERSECTIONS [J].

FAN, ZH ;

HARRISON, DJ .

ANALYTICAL CHEMISTRY, 1994, 66 (01) :177-184

[6]

Grossman P.D., 1992, CAPILLARY ELECTROPHO

[7] TOWARDS MINIATURIZED ELECTROPHORESIS AND CHEMICAL-ANALYSIS SYSTEMS ON SILICON - AN ALTERNATIVE TO CHEMICAL SENSORS [J].

HARRISON, DJ ;

GLAVINA, PG ;

MANZ, A .

SENSORS AND ACTUATORS B-CHEMICAL, 1993, 10 (02) :107-116

[8] CAPILLARY ELECTROPHORESIS AND SAMPLE INJECTION SYSTEMS INTEGRATED ON A PLANAR GLASS CHIP [J].

HARRISON, DJ ;

MANZ, A ;

FAN, ZH ;

LUDI, H ;

WIDMER, HM .

ANALYTICAL CHEMISTRY, 1992, 64 (17) :1926-1932

[9]

Heimenz P.C., 1986, Principles of colloid and surface chemistry

[10] The cataphoresis of suspended particles Part I - The equation of cataphoresis [J].

Henry, DC .

PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES A-CONTAINING PAPERS OF A MATHEMATICAL AND PHYSICAL CHARACTER, 1931, 133 (821) :106-129

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