The tumor suppressor role of miR-155-5p in gastric cancer

被引：38

作者：

Li, Shiqing ^{[1
]}

Zhang, Tao ^{[1
]}

Zhou, Xiaoqing ^{[1
]}

Du, Zonghan ^{[1
]}

Chen, Fumin ^{[1
]}

Luo, Jun ^{[1
]}

Liu, Qingsong ^{[2
]}

机构：

[1] North Sichuan Med Coll, Clin Coll 2, Ctr Hosp Nanchong City, Dept Gastroenterol, Nanchong 637000, Sichuan, Peoples R China

[2] North Sichuan Med Coll, Affiliated Hosp, Clin Lab Dept, 63 Wenhua Rd, Nanchong 637000, Sichuan, Peoples R China

来源：

ONCOLOGY LETTERS | 2018年 / 16卷 / 02期

关键词：

microRNA-155-5p; proliferation; apoptosis; gastric cancer; INHIBITS HEPATOCELLULAR-CARCINOMA; CELL-PROLIFERATION; PROGNOSIS; PROMOTES; METASTASIS; GROWTH; EXPRESSION; INVASION;

D O I：

10.3892/ol.2018.8932

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gastric cancer (GC) is the fifth most common type of malignant tumor worldwide and the most common cause of cancer-associated mortality in China. Recent studies revealed that microRNAs (miRNAs) function in the pathogenesis of GC, and that miR-155-5p expression is downregulated in GC tissues. However, the function of miR-155-5p has not been fully identified. In the present study, it was demonstrated that overexpression of miR-155-5p inhibited GC-cell proliferation and promoted apoptosis, while downregulation of miR-155-5p promoted GC-cell proliferation and decreased the cisplatin sensitivity of GC cells. Mitogen-activated protein kinase kinase kinase 10 was demonstrated to be a potential target gene of miR-155-5p. In conclusion, an antitumor role of miR-155-5p in gastric cancer was suggested.

引用

页码：2709 / 2714

页数：6

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