Bacteriophage resistance mechanisms

被引:1708
作者
Labrie, Simon J. [2 ]
Samson, Julie E. [1 ,3 ,4 ]
Moineau, Sylvain [1 ,3 ,4 ]
机构
[1] Univ Laval, Fac Sci & Genie, Dept Biochem & Microbiol, Quebec City, PQ G1V 0A6, Canada
[2] MIT, Dept Civil & Environm Engn, Cambridge, MA 02139 USA
[3] Univ Laval, Fac Med Dent, Grp Rech Ecol Buccale, Quebec City, PQ G1V 0A6, Canada
[4] Univ Laval, Felix dHerelle Reference Ctr Bacterial Viruses, Quebec City, PQ G1V 0A6, Canada
基金
加拿大健康研究院; 加拿大自然科学与工程研究理事会;
关键词
ABORTIVE INFECTION MECHANISM; DIVERSITY-GENERATING RETROELEMENTS; PROVIDES ACQUIRED-RESISTANCE; LACTOCOCCAL PLASMID PNP40; ESCHERICHIA-COLI K-12; LACTIS SUBSP LACTIS; SUPERINFECTION EXCLUSION; PSEUDOMONAS-AERUGINOSA; PHAGE INFECTION; STREPTOCOCCUS-THERMOPHILUS;
D O I
10.1038/nrmicro2315
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Phages are now acknowledged as the most abundant microorganisms on the planet and are also possibly the most diversified. This diversity is mostly driven by their dynamic adaptation when facing selective pressure such as phage resistance mechanisms, which are widespread in bacterial hosts. When infecting bacterial cells, phages face a range of antiviral mechanisms, and they have evolved multiple tactics to avoid, circumvent or subvert these mechanisms in order to thrive in most environments. In this Review, we highlight the most important antiviral mechanisms of bacteria as well as the counter-attacks used by phages to evade these systems.
引用
收藏
页码:317 / 327
页数:11
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