Association of NQO1Pro187Ser polymorphism with clinical outcomes and survival of lung cancer patients treated with platinum chemotherapy

被引:2
作者
Walia, Harleen Kaur [1 ]
Singh, Navneet [2 ]
Sharma, Siddharth [1 ]
机构
[1] Thapar Inst Engn & Technol, Dept Biotechnol, Patiala, Punjab, India
[2] Post Grad Inst Med Educ & Res PGIMER, Dept Pulm Med, Chandigarh, India
关键词
association; chemotherapy; cisplatin; lung cancer; NQO1; overall survival; pack years; polymorphism; smoking; variant genotype; NAD(P)HQUINONE OXIDOREDUCTASE 1; NQO1 PRO187SER POLYMORPHISM; PREDICTS POOR-PROGNOSIS; GENETIC POLYMORPHISMS; C609T POLYMORPHISM; NAD(P)H-QUINONE-OXIDOREDUCTASE-1 NQO1; RISK; OVEREXPRESSION; SUSCEPTIBILITY; EXPRESSION;
D O I
10.2217/pme-2020-0119
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Background: The study was carried out to evaluate the association of NQO1 P187S polymorphism in North Indian lung cancer (LC) patients. We determined the effect of this polymorphic variant on the survival of LC patients. Patients & methods/results: This case-control study comprised a total of 1100 subjects. The genotyping was carried out using PCR-RFLP and statistical analysis was carried out. The variant TT genotype exhibited 3.5-fold higher odds in subjects with stage III (p = 0.0006), fivefold higher odds of lymph-node invasion (p = 0.007) and an odd of <1 in case of metastasis (p = 0.0028). Patients possessing TT genotype and administered with paclitaxel, exhibited a poor survival (3.57 vs 12.20 months; hazard ratio = 7.95; p = 0.0098). Conclusion: These results suggest that NQO1 variant genotype was not found to modulate risk toward LC. However, the variant genotype was found to be strongly correlated with stage III LC, lymph node invasion and was found to be positively correlating with metastasis.
引用
收藏
页码:333 / 346
页数:14
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