Gastric Cancer Stem Cells: Current Insights into the Immune Microenvironment and Therapeutic Targets

被引：25
作者：
Fu, Lingfeng [1 ,2 ]
Bu, Luke [1 ,2 ]
Yasuda, Tadahito [1 ,2 ]
Koiwa, Mayu [1 ,2 ]
Akiyama, Takahiko [1 ,2 ]
Uchihara, Tomoyuki [1 ,2 ]
Baba, Hideo [2 ]
Ishimoto, Takatsugu [1 ,2 ]
机构：
[1] Kumamoto Univ, IRCMS, Gastrointestinal Canc Biol, Kumamoto 8600811, Japan
[2] Kumamoto Univ, Grad Sch Med Sci, Dept Surg Gastroenterol, 1-1-1 Honjo, Kumamoto 8608556, Japan
来源：
BIOMEDICINES | 2020年 / 8卷 / 01期
基金：
日本学术振兴会;
关键词：
gastric cancer; gastric cancer stem cell; immune microenvironment; cancer therapy; TUMOR-ASSOCIATED MACROPHAGES; BIVATUZUMAB MERTANSINE; INITIATING CELLS; CD44; CARCINOMA; RESPONSES; GROWTH; HIPPO; CD133; TUMORIGENICITY;
D O I：
10.3390/biomedicines8010007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Gastric cancer (GC) is a leading cause of cancer-related death worldwide. Cancer stem cells (CSCs) are known to be involved in chemotherapy resistance and the development of metastases. Although CSCs harbor self-renewal and tumorigenic abilities, the immune microenvironment surrounding CSCs provides various factors and supports the maintenance of CSC properties. The current review summarizes the accumulating findings regarding the relationship between the immune microenvironment and gastric CSCs (GCSCs), which will support the possibility of developing novel therapeutic strategies for targeting GCSCs.
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页数：10
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