Psoriasis-like Dermatitis in Adulthood: A Skin Manifestation of Holocarboxylase Synthetase Deficiency

被引：3

作者：

Watabe, Daisuke ^{[1
]}

Watanabe, Ayano ^{[1
]}

Akasaka, Toshihide ^{[2
]}

Sakamoto, Osamu ^{[3
]}

Amano, Hiroo ^{[1
]}

机构：

[1] Iwate Med Univ, Sch Med, Dept Dermatol, 19-1 Uchimaru, Morioka, Iwate 0208505, Japan

[2] Kitakami Saiseikai Hosp, Div Dermatol, Kitakami, Iwate, Japan

[3] Tohoku Univ, Sch Med, Dept Pediat, Sendai, Miyagi, Japan

来源：

ACTA DERMATO-VENEREOLOGICA | 2018年 / 98卷 / 08期

关键词：

BIOTIN DEFICIENCY;

D O I：

10.2340/00015555-2954

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Holocarboxylase synthetase deficiency (HCSD) is a rare autosomal recessive disorder of biotin metabolism (1). Holocarboxylase synthetase (HCS) plays an essential role in biotin utilization in cells, and its deficiency causes biotin-responsive multiple carboxylase deficiency (MCD) in humans (2). Most patients with HCSD develop symptoms within the first few days or first 2 months of life. The clinical symptoms include tachypnoea, feeding difficulties, seizures, and dermatitis in the early infant period. We report here a case of HCSD presenting as persistent psoriasis-like dermatitis in adulthood.

引用

页码：805 / 806

页数：2

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