Bovine TMEM95 gene: Polymorphisms detecting in five Chinese indigenous cattle breeds and their association with growth traits

被引：3

作者：

Guo, Xian ^{[1
,2
]}

Zhang, Sihuan ^{[3
]}

Yang, Han ^{[3
]}

Pei, Jie ^{[1
,2
]}

Wu, Xiaoyun ^{[1
,2
]}

Bao, Pengjia ^{[1
,2
]}

Liang, Chunnian ^{[1
,2
]}

Xiong, Lin ^{[1
,2
]}

Chu, Min ^{[1
,2
]}

Lan, Xianyong ^{[3
]}

Yan, Ping ^{[1
,2
]}

机构：

[1] Chinese Acad Agr Sci, Lanzhou Inst Husb & Pharmaceut Sci, Lanzhou 730050, Gansu, Peoples R China

[2] Key Lab Yak Breeding Engn Gansu Prov, Lanzhou 730050, Gansu, Peoples R China

[3] Northwest A&F Univ, Coll Anim Sci & Technol, Shaanxi Key Lab Mol Biol Agr, Yangling 712100, Shaanxi, Peoples R China

来源：

ELECTRONIC JOURNAL OF BIOTECHNOLOGY | 2021年 / 51卷

基金：

中国国家自然科学基金;

关键词：

Allelic frequencies; Body growth traits; Cattle; Chinese cattle; Function prediction; Genetic variations; Genotypic frequencies; Livestock; Molecular breeding; Single nucleotide polymorphism (SNP); Transmembrane protein 95 (TMEM95) gene; LITTER SIZE; MUTATION; NUCLEOTIDE; IDENTIFICATION; TRANSCRIPT; EXPRESSION; PLATFORM; MUSCLE; PCR;

D O I：

10.1016/j.ejbt.2021.03.004

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Background: Transmembrane protein 95 (TMEM95) plays a role in male fertility. Previous studies showed that genes with a significant impact on reproductive traits can also affect the growth traits of livestock. Thus, we speculated that the genetic variation of TMEM95 gene may have effects on growth traits of cattle. Results: Two SNPs were genotyped. The rs136174626 and rs41904693 were in the intron 4 and 3'-untranslated region, respectively. The linkage disequilibrium analysis illustrated that these two loci were not linked. The rs136174626 was associated with six growth traits of Nanyang cattle, four traits of Luxi cattle, and three traits of Ji'an cattle. For rs41904693 locus, the GG individuals had greater body height and abdominal girth in Ji' an cattle than TT and TG individuals. In Jinnan cattle, GG and TT individuals had greater body height, height at hip cross, body length, and heart girth than TG individuals. The potential splice site prediction results suggest that the rs136174626 may influence the splicing efficiency of TMEM95, and the miRNA binding site prediction results showed that the rs41904693 may influence the expression of TMEM95 by affecting the binding efficiency of Bta-miR-1584 and TMEM95 30-UTR. Conclusions: The findings of the study suggested that the two SNPs in TMEM95 could be a reliable basis for molecular breeding in cattle. (C) 2021 Pontificia Universidad Catolica de Valparaiso. Production and hosting by Elsevier B.V.

引用

页码：58 / 66

页数：9

共 39 条

[1] Single-nucleotide polymorphisms g.151435C>T and g.173057T>C in PRLR gene regulated by bta-miR-302a are associated with litter size in goats [J].

An, Xiaopeng ;

Hou, Jinxing ;

Gao, Teyang ;

Lei, Yingnan ;

Li, Guang ;

Song, Yuxuan ;

Wang, Jiangang ;

Cao, Binyun .

THERIOGENOLOGY, 2015, 83 (09) :1477-1483

[2] IGF2 antisense transcript expression in porcine postnatal muscle is affected by a quantitative trait nucleotide in intron 3 [J].

Braunschweig, MH ;

Van Laere, AS ;

Buys, N ;

Andersson, L ;

Andersson, G .

GENOMICS, 2004, 84 (06) :1021-1029

[3] ESEfinder: a web resource to identify exonic splicing enhancers [J].

Cartegni, L ;

Wang, JH ;

Zhu, ZW ;

Zhang, MQ ;

Krainer, AR .

NUCLEIC ACIDS RESEARCH, 2003, 31 (13) :3568-3571

[4] An enhanced computational platform for investigating the roles of regulatory RNA and for identifying functional RNA motifs [J].

Chang, Tzu-Hao ;

Huang, Hsi-Yuan ;

Hsu, Justin Bo-Kai ;

Weng, Shun-Long ;

Horng, Jorng-Tzong ;

Huang, Hsien-Da .

BMC BIOINFORMATICS, 2013, 14

[5] Whole-genome resequencing reveals world-wide ancestry and adaptive introgression events of domesticated cattle in East Asia [J].

Chen, Ningbo ;

Cai, Yudong ;

Chen, Qiuming ;

Li, Ran ;

Wang, Kun ;

Huang, Yongzhen ;

Hu, Songmei ;

Huang, Shisheng ;

Zhang, Hucai ;

Zheng, Zhuqing ;

Song, Weining ;

Ma, Zhijie ;

Ma, Yun ;

Dang, Ruihua ;

Zhang, Zijing ;

Xu, Lei ;

Jia, Yutang ;

Liu, Shanzhai ;

Yue, Xiangpeng ;

Deng, Weidong ;

Zhang, Xiaoming ;

Sun, Zhouyong ;

Lan, Xianyong ;

Han, Jianlin ;

Chen, Hong ;

Bradley, Daniel G. ;

Jiang, Yu ;

Le, Chuzhao .

NATURE COMMUNICATIONS, 2018, 9

[6] Effect of BMPRIB gene on litter size of sheep in China: A meta-analysis [J].

Chong, Yuqing ;

Liu, Guiqiong ;

Jiang, Xunping .

ANIMAL REPRODUCTION SCIENCE, 2019, 210

[7] A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep [J].

Clop, Alex ;

Marcq, Fabienne ;

Takeda, Haruko ;

Pirottin, Dimitri ;

Tordoir, Xavier ;

Bibe, Bernard ;

Bouix, Jacques ;

Caiment, Florian ;

Elsen, Jean-Michel ;

Eychenne, Francis ;

Larzul, Catherine ;

Laville, Elisabeth ;

Meish, Francoise ;

Milenkovic, Dragan ;

Tobin, James ;

Charlier, Carole ;

Georges, Michel .

NATURE GENETICS, 2006, 38 (07) :813-818

[8] Insertion/Deletion Within the KDM6A Gene Is Significantly Associated With Litter Size in Goat [J].

Cui, Yang ;

Yan, Hailong ;

Wang, Ke ;

Xu, Han ;

Zhang, Xuelian ;

Zhu, Haijing ;

Liu, Jinwang ;

Qu, Lei ;

Lan, Xianyong ;

Pan, Chuanying .

FRONTIERS IN GENETICS, 2018, 9

[9] Identification of bovine NPC1 gene cSNPs and their effects on body size traits of Qinchuan cattle [J].

Dang, Yonglong ;

Li, Mingxun ;

Yang, Mingjuan ;

Cao, Xiukai ;

Lan, Xianyong ;

Lei, Chuzhao ;

Zhang, Chunlei ;

Lin, Qing ;

Chen, Hong .

GENE, 2014, 540 (02) :153-160

[10]

Dekkers J C M, 2004, J Anim Sci, V82 E-Suppl, pE313

← 1 2 3 4 →