Effects of loud noise exposure on DNA integrity in rat adrenal gland

被引：35

作者：

Frenzilli, G ^{[1
]}

Lenzi, P ^{[1
]}

Scarcelli, V ^{[1
]}

Fornai, F ^{[1
]}

Pellegrini, A ^{[1
]}

Soldani, P ^{[1
]}

Paparelli, A ^{[1
]}

Nigro, M ^{[1
]}

机构：

[1] Univ Pisa, Dipartimento Morfol Umana & Biol Applicata, Sez Biol & Genet, I-56126 Pisa, Italy

来源：

ENVIRONMENTAL HEALTH PERSPECTIVES | 2004年 / 112卷 / 17期

关键词：

adrenal gland; comet assay; DNA damage; loud noise; rat;

D O I：

10.1289/ehp.7249

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Loud noise is generally considered an environmental stressor causing negative effects on acoustic, cardiovascular, nervous, and endocrine systems. In this study, we investigated the effects of noise exposure on DNA integrity in rat adrenal gland evaluated by the comet assay. The exposure to loud noise (100 dBA) for 12 hr caused a significant increase of DNA damage in the adrenal gland. Genetic alterations did not decrease 24 hr after the cessation of the stimulus. We hypothesize that an imbalance of redox cell status is responsible for the induction and persistence of noise-induced cellular damage.

引用

页码：1671 / 1672

页数：2

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