Defatting strategies in the current era of liver steatosis

被引：20
作者：
Mazilescu, Laura Ioana [1 ,2 ,3 ]
Selzner, Markus [1 ]
Selzner, Nazia [1 ]
机构：
[1] Toronto Gen Hosp, Ajmera Transplant Program, Toronto, ON, Canada
[2] Hosp Sick Children, Div Nephrol, Toronto, ON, Canada
[3] Univ Hosp Essen, Dept Gen Visceral & Transplantat Surg, Essen, Germany
来源：
JHEP REPORTS | 2021年 / 3卷 / 03期
关键词：
Macrosteatosis; ischemia-reperfusion injury; machine perfusion; liver transplantation; NONALCOHOLIC FATTY LIVER; HEPATIC STEATOSIS; CULTURED-HEPATOCYTES; MACHINE PERFUSION; LIPID-METABOLISM; PPAR-DELTA; TRANSPLANTATION; STEATOHEPATITIS; PRESERVATION; MACROSTEATOSIS;
D O I：
10.1016/j.jhepr.2021.100265
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Liver steatosis is emerging as a major cause of chronic liver disease worldwide, mainly due to the increasing rate of obesity, type 2 diabetes, and metabolic syndrome. Because of the increased incidence of liver steatosis, many organs are currently declined for transplantation despite high demand and waiting list mortality. Defatting strategies have recently emerged as a means of rapidly reducing liver steatosis to expand the pool of available organs. This review summarises advances in defatting strategies in experimental and human models of liver steatosis over the last 20 years. (C) 2021 Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL).
引用
收藏
页数：8
相关论文
共 50 条
[41]   If steatosis is the atherosclerosis of the liver, are statins the "aspirin" for steatosis? [J].
Lonardo, Amedeo ;
Loria, Paola .
DIGESTIVE AND LIVER DISEASE, 2012, 44 (06) :451-452
[42]   Extracellular Vesicles in Liver Transplantation: Current Evidence and Future Challenges [J].
De Stefano, Nicola ;
Calleri, Alberto ;
Faini, Angelo Corso ;
Navarro-Tableros, Victor ;
Martini, Silvia ;
Deaglio, Silvia ;
Patrono, Damiano ;
Romagnoli, Renato .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (17)
[43]   Effect of liver steatosis in outcome after bile duct reconstruction for iatrogenic injury [J].
Angel Mercado-Diaz, Miguel ;
Urencio-Marcue, Miguel ;
Ramirez-Del Val, Fernando ;
Dominguez-Rosado, Ismael .
CIRUGIA Y CIRUJANOS, 2010, 78 (02) :141-145
[44]   Effect of Donor Hepatic Steatosis on Ischemia Reperfusion Injury in Liver Transplant Recipient [J].
Jadhav, Prafulla, V ;
Kothakota, Sunil Raviraj ;
Sasidharan, Madhu ;
Kareem, Harish ;
Nair, Ajith K. .
JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY, 2020, 10 (03) :236-244
[45]   Mapping the triglyceride distribution in NAFLD human liver by MALDI imaging mass spectrometry reveals molecular differences in micro and macro steatosis [J].
Alamri, Hussam ;
Patterson, Nathan Heath ;
Yang, Ethan ;
Zoroquiain, Pablo ;
Lazaris, Anthoula ;
Chaurand, Pierre ;
Metrakos, Peter .
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2019, 411 (04) :885-894
[46]   Natural History of Hepatic Steatosis: Observed Outcomes for Subsequent Liver and Cardiovascular Complications [J].
Pickhardt, Perry J. ;
Hahn, Luke ;
del Rio, Alejandro Munoz ;
Park, Seong Ho ;
Reeder, Scott B. ;
Said, Adnan .
AMERICAN JOURNAL OF ROENTGENOLOGY, 2014, 202 (04) :752-758
[47]   Steatosis After Liver Transplantation: Is It Really Benign? [J].
Finkenstedt, Armin ;
Graziadei, Ivo W. .
LIVER TRANSPLANTATION, 2016, 22 (05) :585-587
[48]   Focal hypersteatosis: a pseudolesion in patients with liver steatosis [J].
Metin, Nurgul Orhan ;
Karaosmanoglu, Ali Devrim ;
Metin, Yavuz ;
Karcaaltincaba, Musturay .
DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY, 2019, 25 (01) :14-20
[49]   Assessment of donor steatosis in liver transplantation: is it possible without liver biopsy? [J].
Cucchetti, Alessandro ;
Vivarelli, Marco ;
Ravaioli, Matteo ;
Cescon, Matteo ;
Ercolani, Giorgio ;
Piscaglia, Fabio ;
Del Gaudio, Massimo ;
Grazi, Gian Luca ;
Ridolfi, Lorenza ;
Pinna, Antonio Daniele .
CLINICAL TRANSPLANTATION, 2009, 23 (04) :519-524
[50]   Machine perfusion strategies in liver transplantation [J].
Schlegel, Andrea ;
Muller, Xavier ;
Dutkowski, Philipp .
HEPATOBILIARY SURGERY AND NUTRITION, 2019, 8 (05) :490-501
12345