Defatting strategies in the current era of liver steatosis

被引：20

作者：

Mazilescu, Laura Ioana ^{[1
,2
,3
]}

Selzner, Markus ^{[1
]}

Selzner, Nazia ^{[1
]}

机构：

[1] Toronto Gen Hosp, Ajmera Transplant Program, Toronto, ON, Canada

[2] Hosp Sick Children, Div Nephrol, Toronto, ON, Canada

[3] Univ Hosp Essen, Dept Gen Visceral & Transplantat Surg, Essen, Germany

来源：

JHEP REPORTS | 2021年 / 3卷 / 03期

关键词：

Macrosteatosis; ischemia-reperfusion injury; machine perfusion; liver transplantation; NONALCOHOLIC FATTY LIVER; HEPATIC STEATOSIS; CULTURED-HEPATOCYTES; MACHINE PERFUSION; LIPID-METABOLISM; PPAR-DELTA; TRANSPLANTATION; STEATOHEPATITIS; PRESERVATION; MACROSTEATOSIS;

D O I：

10.1016/j.jhepr.2021.100265

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Liver steatosis is emerging as a major cause of chronic liver disease worldwide, mainly due to the increasing rate of obesity, type 2 diabetes, and metabolic syndrome. Because of the increased incidence of liver steatosis, many organs are currently declined for transplantation despite high demand and waiting list mortality. Defatting strategies have recently emerged as a means of rapidly reducing liver steatosis to expand the pool of available organs. This review summarises advances in defatting strategies in experimental and human models of liver steatosis over the last 20 years. (C) 2021 Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL).

引用

页数：8

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