Defatting strategies in the current era of liver steatosis

被引：20

作者：

Mazilescu, Laura Ioana ^{[1
,2
,3
]}

Selzner, Markus ^{[1
]}

Selzner, Nazia ^{[1
]}

机构：

[1] Toronto Gen Hosp, Ajmera Transplant Program, Toronto, ON, Canada

[2] Hosp Sick Children, Div Nephrol, Toronto, ON, Canada

[3] Univ Hosp Essen, Dept Gen Visceral & Transplantat Surg, Essen, Germany

来源：

JHEP REPORTS | 2021年 / 3卷 / 03期

关键词：

Macrosteatosis; ischemia-reperfusion injury; machine perfusion; liver transplantation; NONALCOHOLIC FATTY LIVER; HEPATIC STEATOSIS; CULTURED-HEPATOCYTES; MACHINE PERFUSION; LIPID-METABOLISM; PPAR-DELTA; TRANSPLANTATION; STEATOHEPATITIS; PRESERVATION; MACROSTEATOSIS;

D O I：

10.1016/j.jhepr.2021.100265

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Liver steatosis is emerging as a major cause of chronic liver disease worldwide, mainly due to the increasing rate of obesity, type 2 diabetes, and metabolic syndrome. Because of the increased incidence of liver steatosis, many organs are currently declined for transplantation despite high demand and waiting list mortality. Defatting strategies have recently emerged as a means of rapidly reducing liver steatosis to expand the pool of available organs. This review summarises advances in defatting strategies in experimental and human models of liver steatosis over the last 20 years. (C) 2021 Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL).

引用

页数：8

共 50 条

[21] Non-contrasted Computed Tomography for the Accurate Measurement of Liver Steatosis in Obese Patients [J].

Shores, Nathan J. ;

Link, Kerry ;

Fernandez, Adolfo ;

Geisinger, Kim R. ;

Davis, Matt ;

Nguyen, Tam ;

Sawyer, Janet ;

Rudel, Larry .

DIGESTIVE DISEASES AND SCIENCES, 2011, 56 (07) :2145-2151

[22] Mitochondrial Targeting Therapy Role it Liver Transplant Preservation Lines: Mechanism and Therapeutic Strategies [J].

Tara, Anjli ;

Dominic, Jerry Lorren ;

Patel, Jaimin N. ;

Garg, Ishan ;

Yeon, Jimin ;

Memon, Marrium S. ;

Rao, Sanjay Rao Gergal Gopalkrishna ;

Bugazia, Seif ;

Dhandapani, Tamil Poonkuil Mozhi ;

Kannan, Amudhan ;

Kantamaneni, Ketan ;

Win, Myat ;

Went, Terry R. ;

Yanamala, Vijaya Lakshmi ;

Mostafa, Jihan A. .

CUREUS JOURNAL OF MEDICAL SCIENCE, 2021, 13 (07)

[23] Current Strategies to Minimize Ischemia-Reperfusion Injury in Liver Transplantation: A Systematic Review [J].

Gazia, Carlo ;

Lenci, Ilaria ;

Manzia, Tommaso M. ;

Martina, Milana ;

Tisone, Giuseppe ;

Angelico, Roberta ;

Abenavoli, Ludovico ;

Grassi, Giuseppe ;

Signorello, Alessandro ;

Baiocchi, Leonardo .

REVIEWS ON RECENT CLINICAL TRIALS, 2021, 16 (04) :372-380

[24] Spontaneous liver steatosis in waterfowls: overview on current research and perspectives [J].

Knudsen, Christelle ;

Bonnefont, Cecile ;

Fortun-Lamothe, Laurence ;

Ricaud, Karine ;

Fernandez, Xavier .

INRA PRODUCTIONS ANIMALES, 2018, 31 (02) :117-129

[25] The impact of steatosis on liver regeneration [J].

Allaire, Manon ;

Gilgenkrantz, Helene .

HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION, 2020, 41 (01)

[26] Does Hepatic Steatosis Affect Drug Metabolizing Enzymes in the Liver? [J].

Buechler, Christa ;

Weiss, Thomas S. .

CURRENT DRUG METABOLISM, 2011, 12 (01) :24-34

[27] Impact of Graft Steatosis on Postoperative Complications after Liver Transplantation [J].

Ahmed, Emad Ali ;

El-Badry, Ashraf Mohammad ;

Mocchegiani, Federico ;

Montalti, Roberto ;

Hassan, Asem Elsani Ali ;

Redwan, Alaa Ahmed ;

Vivarelli, Marco .

SURGERY JOURNAL, 2018, 4 (04) :E188-E196

[28] Novel strategies in liver graft preservation The French perspective [J].

Muller, X. ;

Rossignol, G. ;

Mohkam, K. ;

Mabrut, J. Y. .

JOURNAL OF VISCERAL SURGERY, 2022, 159 (05) :389-398

[29] Steatosis in the Liver [J].

Wang, David Q-H ;

Portincasa, Piero ;

Neuschwander-Tetri, Brent A. .

COMPREHENSIVE PHYSIOLOGY, 2013, 3 (04) :1493-1532

[30] Combined Computational Fluid Dynamic and Metabolic Model of Liver Defatting Under Flow [J].

Saleem, Mubasher ;

Maguire, Timothy J. .

2014 40TH ANNUAL NORTHEAST BIOENGINEERING CONFERENCE (NEBEC), 2014,

← 1 2 3 4 5 →