Towards clinically translatable in vivo nanodiagnostics

被引：255

作者：

Park, Seung-min ^{[1
,2
]}

Aalipour, Amin ^{[1
,2
]}

Vermesh, Ophir ^{[1
,2
]}

Yu, Jung Ho ^{[1
,2
]}

Gambhir, Sanjiv S. ^{[1
,2
,3
]}

机构：

[1] Stanford Univ, Sch Med, Dept Radiol, 300 Pasteur Dr, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Mol Imaging Program Stanford, 300 Pasteur Dr, Stanford, CA 94305 USA

[3] Stanford Univ, Sch Med, Canary Ctr Stanford Canc Early Detect, 3155 Porter Dr, Palo Alto, CA 94304 USA

来源：

NATURE REVIEWS MATERIALS | 2017年 / 2卷 / 05期

基金：

美国国家卫生研究院;

关键词：

SUPERPARAMAGNETIC IRON-OXIDE; LYMPH-NODE METASTASES; BIOCOMPATIBLE CONDENSATION REACTION; CARDIOVASCULAR MAGNETIC-RESONANCE; ACUTE MYOCARDIAL-INFARCTION; PROTEIN CORONA COMPOSITION; CANCER-TARGETED PROBES; IMAGING CURRENT STATUS; GOLD NANOPARTICLES; QUANTUM DOTS;

D O I：

10.1038/natrevmats.2017.14

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Nanodiagnostics as a field makes use of fundamental advances in nanobiotechnology to diagnose, characterize and manage disease at the molecular scale. As these strategies move closer to routine clinical use, a proper understanding of different imaging modalities, relevant biological systems and physical properties governing nanoscale interactions is necessary to rationally engineer next-generation bionanomaterials. In this Review, we analyse the background physics of several clinically relevant imaging modalities and their associated sensitivity and specificity, provide an overview of the materials currently used for in vivo nanodiagnostics, and assess the progress made towards clinical translation. This work provides a framework for understanding both the impressive progress made thus far in the nanodiagnostics field as well as presenting challenges that must be overcome to obtain widespread clinical adoption.

引用

页数：19

共 214 条

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