Pulmonary hypertension in patients with heart failure and preserved ejection fraction: differential diagnosis and management

被引：18

作者：

Hussain, Nehal ^{[1
]}

Charalampopoulos, Athanasios ^{[1
]}

Ramjug, Sheila ^{[1
]}

Condliffe, Robin ^{[1
]}

Elliot, Charlie A. ^{[1
]}

O'Toole, Laurence ^{[2
]}

Swift, Andrew ^{[3
]}

Kiely, David G. ^{[1
]}

机构：

[1] Sheffield Natl Hlth Serv NHS Teaching Hosp Fdn Tr, Sheffield Pulm Vasc Dis Unit, Royal Hallamshire Hosp, Sheffield, S Yorkshire, England

[2] Sheffield NHS Teaching Hosp Fdn Trust, Dept Cardiol, No Gen Hosp, Sheffield, S Yorkshire, England

[3] Univ Sheffield, Royal Hallamshire Hosp, Acad Unit Radiol, Sheffield NHS Teaching Hosp Fdn Trust, Sheffield S10 2JF, S Yorkshire, England

来源：

PULMONARY CIRCULATION | 2016年 / 6卷 / 01期

关键词：

pulmonary arterial hypertension; combined pre- and postcapillary pulmonary hypertension; heart failure with preserved ejection fraction; diastolic dysfunction; CAPILLARY WEDGE PRESSURE; LEFT-VENTRICULAR DYSFUNCTION; ARTERIAL-HYPERTENSION; PROGNOSTIC VALUE; METABOLIC SYNDROME; SYSTOLIC FUNCTION; DOUBLE-BLIND; PHOSPHODIESTERASE-5; INHIBITION; CLINICAL CHARACTERISTICS; DIASTOLIC DYSFUNCTION;

D O I：

10.1086/685021

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The most common cause of pulmonary hypertension (PH) due to left heart disease (LHD) was previously rheumatic mitral valve disease. However, with the disappearance of rheumatic fever and an aging population, nonvalvular LHD is now the most common cause of group 2 PH in the developed world. In this review, we examine the challenge of investigating patients who have PH and heart failure with preserved ejection fraction (HF-pEF), where differentiating between pulmonary arterial hypertension (PAH) and PH-LHD can be difficult, and also discuss the entity of combined precapillary and postcapillary PH. Given the proven efficacy of targeted therapy for the treatment of PAH, there is increasing interest in whether these treatments may benefit selected patients with PH associated with HF-pEF, and we review current trial data.

引用

页码：3 / 14

页数：12

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