Caloric restriction and exercise "mimetics": Ready for prime time?

被引：52
作者：
Handschin, Christoph [1 ]
机构：
[1] Univ Basel, Biozentrum, Klingelbergstr 50-70, CH-4056 Basel, Switzerland
来源：
PHARMACOLOGICAL RESEARCH | 2016年 / 103卷
基金：
瑞士国家科学基金会;
关键词：
Skeletal muscle; Exercise; Mimetics; Resveratrol; PGC-1; alpha; AMPK; PPAR beta/delta; Caloric restriction; Diet; MUSCLE MITOCHONDRIAL-FUNCTION; SMALL-MOLECULE ACTIVATORS; FATTY-ACID OXIDATION; REV-ERB-ALPHA; SKELETAL-MUSCLE; LIFE-SPAN; CARDIOVASCULAR HEALTH; GLUCOSE-HOMEOSTASIS; ENERGY-EXPENDITURE; CIRCADIAN BEHAVIOR;
D O I：
10.1016/j.phrs.2015.11.009
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Exercise and diet are powerful interventions to prevent and ameliorate various pathologies. The development of pharmacological agents that confer exercise- or caloric restriction-like phenotypic effects is thus an appealing therapeutic strategy in diseases or even when used as life-style and longevity drugs. Such so-called exercise or caloric restriction "mimetics" have so far mostly been described in pre-clinical, experimental settings with limited translation into humans. Interestingly, many of these compounds activate related signaling pathways, most often postulated to act on the common downstream effector peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha) in skeletal muscle. In this review, resveratrol and other exercise- and caloric restriction "mimetics" are discussed with a special focus on feasibility, chances and limitations of using such compounds in patients as well as in healthy individuals. (C) 2015 Elsevier Ltd. All rights reserved.
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收藏
页码：158 / 166
页数：9
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