IL-17+CD8+T cells: Differentiation, phenotype and role in inflammatory disease

被引：110

作者：

Srenathan, Ushani ^{[1
]}

Steel, Kathryn ^{[1
]}

Taams, Leonie S. ^{[1
]}

机构：

[1] Kings Coll London, Div Immunol Infect & Inflammatory Dis, Ctr Mol & Cellular Biol Inflammat, 1st Floor New Hunts House,Room 1-26F,Guys Campus, London SE1 1UL, England

来源：

IMMUNOLOGY LETTERS | 2016年 / 178卷

基金：

英国医学研究理事会;

关键词：

CD8+; IL-17; Tc17; Inflammation; Disease; CD8(+) T-CELLS; GROWTH-FACTOR-BETA; ROR-GAMMA-T; TC17; CELLS; IFN-GAMMA; IL-23; PROMOTES; INTERLEUKIN-17; SUBSET; LYMPHOCYTES; PSORIASIS;

D O I：

10.1016/j.imlet.2016.05.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The pro-inflammatory cytokine interleukin-17A (IL-17) has been the subject of research by many groups worldwide. IL-17 expression is often associated with a specific subset of CD4+ T cells (the so-called Th17 cells); however various other immune cell subsets can also synthesise and express IL-17, including CD8+T cells. Here we review recent data regarding the presence of IL-17+ CD8+ T cells (also known as Tc17 cells) in human inflammatory disease, discuss current knowledge regarding the culture conditions required for the differentiation of these cells in humans and mice, and describe key phenotypic and functional features. Collectively, this information may shed light on the potential pathogenic role that IL-17+ CD8+ T cells may play in human inflammatory disease. (C) 2016 The Authors. Published by Elsevier B.V. on behalf of European Federation of Immunological Societies.

引用

页码：20 / 26

页数：7

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