Anaphylaxis associated with the mRNA COVID-19 vaccines: Approach to allergy investigation

被引：25
作者：
Turk, Viktorija Erdeljic [1 ,2 ]
机构：
[1] Univ Hosp Ctr Zagreb, Dept Med, Div Clin Pharmacol, Kispaticeva 12, Zagreb 10000, Croatia
[2] Univ Zagreb, Sch Med, Salata 3, Zagreb 10000, Croatia
来源：
CLINICAL IMMUNOLOGY | 2021年 / 227卷
关键词：
COVID-19; mRNA vaccine; Anaphylaxis; Allergy; Polyethylene glycol; Skin test; POLYETHYLENE-GLYCOL; HYPERSENSITIVITY; ANTIBODIES; PEG;
D O I：
10.1016/j.clim.2021.108748
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Reports about cases of anaphylaxis to mRNA vaccines have created anxiety in the community and could increase vaccine hesitancy in the population. There are no standardized protocols for allergy testing to mRNA vaccines. PEG is currently the only excipient in both vaccines with recognized allergenic potential. Allergy to PEG has been reported with increasing frequency over recent years, often in patients who had repeated systemic allergic reactions/anaphylaxis to several classes of drugs before diagnosis. Proposed protocols are based on current knowledge about potential mechanisms of anaphylaxis associated with the mRNA vaccines, and the assumption that polyethylene glycol (PEG) is the most likely culprit. Allergy testing to PEGs and mRNA vaccines is complex and carries the risk of anaphylaxis and should be conducted in a specialist drug allergy center. Appropriate PEGfree emergency medical treatment and supervision should be readily available.
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页数：5
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