Synthesis and biological evaluation of some 6-substituted purines

被引：34

作者：

Braga, Fernanda Gambogi

Coimbra, Elaine Soares

Matos, Magnum de Oliveira

Lino Carmo, Arturene Maria

Cancio, Marisa Damato

da Silva, Adilson David

机构：

[1] Univ Fed Juiz Fora, Inst Ciencias Exatas, Dept Quim, BR-36036900 Juiz de Fora, MG, Brazil

[2] Univ Fed Juiz Fora, Inst Ciencias Biol, Dept parasitol Microbiol & Imunol, BR-36036900 Juiz de Fora, MG, Brazil

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2007年 / 42卷 / 04期

关键词：

6-substituted purines; antileishmanial activity;

D O I：

10.1016/j.ejmech.2006.10.014

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We report herein the synthesis and the in vitro antileishmanial evaluation of a series of 6-substituted purines. The most active compounds against Leishmania amazonensis promastigotes were 6-(3'-chloropropylthio)purine 2 (D.A. Benson, I. Karsch-Mizrachi, D.J. Lipman, J. Ostell, B.A. Rapp, D.L. Wheeler, Genbank., Nucleic Acids Res. 28 (2000) 15-18; E.V. Aleksandrova, P.M.I.E. Valashek, J. Med. Pharm. Chem. 35 (2001) 172-173), 6-(3'-(thioethylamine)propylthio)purine 5, 6-(alpha-aceticacidthio)purine-7 and 6-(6'-deoxy-1'-O-methyl-beta-D-ribofuranose)purine 14 with an IC50 = 50, 50, 39 and 29 mu M, respectively. (c) 2006 Elsevier Masson SAS. All rights reserved.

引用

收藏

页码：530 / 537

页数：8

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