Recurrent non-functioning pituitary adenomas: a review on the new pathological classification, management guidelines and treatment options

被引:30
作者
Delgado-Lopez, P. D. [1 ]
Pi-Barrio, J. [2 ]
Duenas-Polo, M. T. [3 ]
Pascual-Llorente, M. [4 ]
Gordon-Bolanos, M. C. [5 ]
机构
[1] Hosp Univ Burgos, Serv Neurocirugia, Avda Islas Baleares 3, Burgos 09006, Spain
[2] Hosp Univ Burgos, Serv Endocrinol & Nutr, Burgos, Spain
[3] Hosp Univ Burgos, Serv Oncol Radioterap, Burgos, Spain
[4] Hosp Univ Burgos, Serv Anat Patol, Burgos, Spain
[5] Hosp Univ Burgos, Serv Oftalmol, Burgos, Spain
关键词
Non-functioning pituitary adenoma; Radiotherapy; Recurrence; Cabergoline; Temozolomide; Transsphenoidal approach; Guidelines; Transcription factor; OPTICAL COHERENCE TOMOGRAPHY; CAVERNOUS SINUS SPACE; CONSERVATIVE SURGERY; SINGLE-CENTER; TUMORS; THERAPY; RADIOTHERAPY; MORTALITY; RISK; PERSPECTIVES;
D O I
10.1007/s12094-018-1868-6
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
At least 50% of surgically resected non-functioning pituitary adenomas (NFPA) recur. Either early or late adjuvant radiotherapy is highly efficacious in controlling recurrent NFPA but associates potentially burdensome complications like hypopituitarism, vascular complications or secondary neoplasm. Reoperation is indicated in bulky tumor rests compressing the optic pathway. To date, no standardized medical therapy is available for recurrent NFPA although cabergoline and temozolomide show promising results. Guidelines on the management of recurrent NFPAs are now available. The new 2017 WHO pituitary tumor classification, based on immunohistochemistry and transcription factor assessment, identifies a group of aggressive NFPA variants that may benefit from earlier adjuvant therapy. Nevertheless, NFPA patients exhibit a reduced overall life expectancy largely due to hypopituitarism and treatment-related morbidity. The management of recurrent NFPA benefits from a multidisciplinary teamwork of surgeons, endocrinologists, radiation oncologists, ophthalmologists, pathologists and neuro-radiologists in order to provide individualized therapy and anticipate deterioration.
引用
收藏
页码:1233 / 1245
页数:13
相关论文
共 70 条
[1]   Neuro-ophthalmologic exploration in non-functioning pituitary adenoma [J].
Abouaf, Lucie ;
Vighetto, Alain ;
Lebas, Maud .
ANNALES D ENDOCRINOLOGIE, 2015, 76 (03) :210-219
[2]   Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Management of Patients With Nonfunctioning Pituitary Adenomas: Executive Summary [J].
Aghi, Manish K. ;
Chen, Clark C. ;
Fleseriu, Maria ;
Newman, Steven A. ;
Lucas, Joshua William ;
Kuo, John S. ;
Barkhoudarian, Garni ;
Farrell, Christopher J. ;
Sheehan, Jason ;
Ziu, Mateo ;
Dunn, Ian F. .
NEUROSURGERY, 2016, 79 (04) :521-523
[3]  
Altun Y, 2017, ANN ITAL CHIR, V88, P7
[4]   In vivo secretory potential and the effect of combination therapy with octreotide and cabergoline in patients with clinically non-functioning pituitary adenomas [J].
Andersen, M ;
Bjerre, P ;
Schroder, HD ;
Edal, A ;
Hoilund-Carlsen, PF ;
Pedersen, PH ;
Hagen, C .
CLINICAL ENDOCRINOLOGY, 2001, 54 (01) :23-30
[5]   Long-Term Outcome and MGMT as a Predictive Marker in 24 Patients With Atypical Pituitary Adenomas and Pituitary Carcinomas Given Treatment With Temozolomide [J].
Bengtsson, Daniel ;
Schroder, Henrik Daa ;
Andersen, Marianne ;
Maiter, Dominique ;
Berinder, Katarina ;
Rasmussen, Ulla Feldt ;
Rasmussen, Ase Krogh ;
Johannsson, Gudmundur ;
Hoybye, Charlotte ;
van der Lely, Aart Jan ;
Petersson, Maria ;
Ragnarsson, Oskar ;
Burman, Pia .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2015, 100 (04) :1689-1698
[6]   Somatostatin receptor imaging in somatotroph and non-functioning pituitary adenomas: correlation with hormonal and visual responses to octreotide [J].
BorsonChazot, F ;
Houzard, C ;
Ajzenberg, C ;
Nocaudie, M ;
Duet, M ;
Mundler, O ;
Marchandise, X ;
Epelbaum, J ;
DeAlzaga, MG ;
Schafer, J ;
Meyerhof, W ;
Sassolas, G ;
Warnet, A .
CLINICAL ENDOCRINOLOGY, 1997, 47 (05) :589-598
[7]   THE LONG-TERM EFFICACY OF CONSERVATIVE SURGERY AND RADIOTHERAPY IN THE CONTROL OF PITUITARY-ADENOMAS [J].
BRADA, M ;
RAJAN, B ;
TRAISH, D ;
ASHLEY, S ;
HOLMESSELLORS, PJ ;
NUSSEY, S ;
UTTLEY, D .
CLINICAL ENDOCRINOLOGY, 1993, 38 (06) :571-578
[8]   Pituitary Apoplexy [J].
Briet, Claire ;
Salenave, Sylvie ;
Chanson, Philippe .
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, 2015, 44 (01) :199-+
[9]   Factors predicting relapse of nonfunctioning pituitary macroadenomas after neurosurgery: a study of 142 patients [J].
Brochier, Sophie ;
Galland, Francoise ;
Kujas, Michele ;
Parker, Fabrice ;
Gaillard, Stephan ;
Raftopoulos, Christian ;
Young, Jacques ;
Alexopoulou, Orsalia ;
Maiter, Dominique ;
Chanson, Philippe .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2010, 163 (02) :193-200
[10]   Non-functioning pituitary tumors: 2012 update [J].
Camara Gomez, Rosa .
ENDOCRINOLOGIA Y NUTRICION, 2014, 61 (03) :160-170