An evaluation of the diagnostic equivalence of 18F-FDG-PET between hybrid PET/MRI and PET/CT in drug-resistant epilepsy: A pilot study

被引：17
作者：
Poirier, Stefan E. [1 ,2 ]
Kwan, Benjamin Y. M. [3 ]
Jurkiewicz, Michael T. [4 ]
Samargandy, Lina [4 ]
Iacobelli, Maryssa [1 ]
Steven, David A. [5 ,6 ]
Cheung, Victor Lam Shin [4 ]
Moran, Gerald [7 ]
Prato, Frank S. [1 ,2 ,4 ]
Thompson, R. Terry [1 ,2 ,4 ]
Burneo, Jorge G. [5 ,6 ]
Anazodo, Udunna C. [1 ,2 ,5 ,8 ]
Thiessen, Jonathan D. [1 ,2 ,4 ]
机构：
[1] Lawson Hlth Res Inst, Lawson Imaging, 268 Grosvenor St, London, ON N6A 4V2, Canada
[2] Western Univ, Schulich Sch Med & Dent, Dept Med Biophys, London, ON, Canada
[3] Queens Univ, Dept Diagnost Radiol, Kingston, ON, Canada
[4] Western Univ, Schulich Sch Med & Dent, Dept Med Imaging, London, ON, Canada
[5] Western Univ, Schulich Sch Med & Dent, Dept Clin Neurol Sci, London, ON, Canada
[6] Western Univ, Schulich Sch Med & Dent, Dept Epidemiol & Biostat, London, ON, Canada
[7] Siemens Healthineers, Oakville, ON, Canada
[8] McGill Univ, Res Ctr Studies Aging, Montreal, PQ, Canada
来源：
EPILEPSY RESEARCH | 2021年 / 172卷
关键词：
PET; MRI; CT; Drug-resistant epilepsy; Fluorodeoxyglucose; MRI-based attenuation correction; POSITRON-EMISSION-TOMOGRAPHY; ATTENUATION CORRECTION; MRI; COREGISTRATION; EXPERIENCE; IMAGES;
D O I：
10.1016/j.eplepsyres.2021.106583
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Objective: Hybrid PET/MRI may improve detection of seizure-onset zone (SOZ) in drug-resistant epilepsy (DRE), however, concerns over PET bias from MRI-based attenuation correction (MRAC) have limited clinical adoption of PET/MRI. This study evaluated the diagnostic equivalency and potential clinical value of PET/MRI against PET/CT in DRE. Materials and methods: MRI, FDG-PET and CT images (n = 18) were acquired using a hybrid PET/MRI and a CT scanner. To assess diagnostic equivalency, PET was reconstructed using MRAC (RESOLUTE) and CT-based attenuation correction (CTAC) to generate PET/MRI and PET/CT images, respectively. PET/MRI and PET/CT images were compared qualitatively through visual assessment and quantitatively through regional standardized uptake value (SUV) and z-score assessment. Diagnostic accuracy and sensitivity of PET/MRI and PET/CT for SOZ detection were calculated through comparison to reference standards (clinical hypothesis and histopathology, respectively). Results: Inter-reader agreement in visual assessment of PET/MRI and PET/CT images was 78 % and 81 %, respectively. PET/MRI and PET/CT were strongly correlated in mean SUV (r = 0.99, p < 0.001) and z-scores (r = 0.92, p < 0.001) across all brain regions. MRAC SUV bias was <5% in most brain regions except the inferior temporal gyrus, temporal pole, and cerebellum. Diagnostic accuracy and sensitivity were similar between PET/ MRI and PET/CT (87 % vs. 85 % and 83 % vs. 83 %, respectively). Conclusion: We demonstrate here that PET/MRI with optimal MRAC can yield similar diagnostic performance as PET/CT. Nevertheless, further exploration of the potential added value of PET/MRI is necessary before clinical adoption of PET/MRI for epilepsy imaging.
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页数：9
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