Peptide-Based Vaccines: Foot-and-Mouth Disease Virus, a Paradigm in Animal Health

被引:24
作者
Forner, Mar [1 ]
Canas-Arranz, Rodrigo [2 ]
Defaus, Sira [1 ]
de Leon, Patricia [2 ]
Rodriguez-Pulido, Miguel [2 ]
Ganges, Llilianne [3 ]
Blanco, Esther [4 ]
Sobrino, Francisco [2 ]
Andreu, David [1 ]
机构
[1] UPF, Dept Ciencies Expt & Salut DCEXS, Barcelona 08003, Spain
[2] UAM, CSIC, Ctr Biol Mol Severo Ochoa, Madrid 28049, Spain
[3] Inst Agrifood Res & Technol, OIE Reference Lab Class Swine Fever, Ctr Recerca Sanitat Anim CReSA, Barcelona 08193, Spain
[4] INIA, Ctr Invest Sanidad Anim, Valdeolmos 28130, Spain
关键词
epitope-based vaccines; peptide; vaccines; FMDV; veterinary medicine; CLASSICAL SWINE-FEVER; T-CELL EPITOPE; PROTECTIVE IMMUNE-RESPONSE; VIRAL ANTIGENIC SITE; CLASS-I; NONSTRUCTURAL PROTEINS; TRANSLATION INITIATION; STRUCTURAL PROTEINS; WORLD ORGANIZATION; SURFACE-STRUCTURE;
D O I
10.3390/vaccines9050477
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Vaccines are considered one of the greatest global health achievements, improving the welfare of society by saving lives and substantially reducing the burden of infectious diseases. However, few vaccines are fully effective, for reasons ranging from intrinsic limitations to more contingent shortcomings related, e.g., to cold chain transport, handling and storage. In this context, subunit vaccines where the essential antigenic traits (but not the entire pathogen) are presented in rationally designed fashion have emerged as an attractive alternative to conventional ones. In particular, this includes the option of fully synthetic peptide vaccines able to mimic well-defined B- and T-cell epitopes from the infectious agent and to induce protection against it. Although, in general, linear peptides have been associated to low immunogenicity and partial protection, there are several strategies to address such issues. In this review, we report the progress towards the development of peptide-based vaccines against foot-and-mouth disease (FMD) a highly transmissible, economically devastating animal disease. Starting from preliminary experiments using single linear B-cell epitopes, recent research has led to more complex and successful second-generation vaccines featuring peptide dendrimers containing multiple copies of B- and T-cell epitopes against FMD virus or classical swine fever virus (CSFV). The usefulness of this strategy to prevent other animal and human diseases is discussed.
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页数:21
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