ACID PROMOTED METAL FREE SYNTHESIS OF TRIAZOLE-FUSED HETEROCYCLES VIA INTRAMOLECULAR [3+2] CYCLOADDITION

被引：1

作者：

Zhang, Youlai ^{[1
]}

Wang, Mengdi ^{[1
]}

Li, Junru ^{[1
]}

Di, Qingtong ^{[1
]}

Tian, Ziye ^{[1
]}

Chen, Baoquan ^{[1
]}

Zhang, Huan ^{[1
]}

Tanimoto, Hiroki ^{[2
]}

Morimoto, Tsumoru ^{[2
]}

Kakiuchi, Kiyomi ^{[2
]}

机构：

[1] Tianjin Univ Technol, Sch Chem & Chem Engn, Tianjin Key Lab Organ Solar Cells & Photochem Con, Tianjin 300384, Peoples R China

[2] Nara Inst Sci & Technol NAIST, Grad Sch Mat Sci, 8916-5 Takayama, Nara 6300192, Japan

来源：

HETEROCYCLES | 2018年 / 96卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Triazole-Fused Heterocycle; Cycloaddition Reaction; Azide; CLICK CHEMISTRY; 1,2,3-TRIAZOLES; DERIVATIVES; INHIBITOR; ACCESS;

D O I：

10.3987/COM-18-13900

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical and efficient protocol for the synthesis of triazole-fused heterocycles through intramolecular metal free [3+2] azide-alkyne cycloaddition reaction is described. Range of acids was selected to demonstrate the reaction conditions. Organic azides and propargyl cations generated by acids gave fused triazoles including multivariate rings and heterocycles. Various fused triazoles and bistriazoles were obtained in good yields under mild reaction conditions.

引用

收藏

页码：947 / 957

页数：11

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