Transition-Metal-Free Oxidative Cross-Coupling of Methylhetarenes with Imidazoheterocycles towards Efficient C(sp2)-H Carbonylation

被引：22

作者：

Sultana, Faria ^{[1
]}

Shaik, Siddiq Pasha ^{[1
,2
]}

Alarifi, Abdullah ^{[3
]}

Srivastava, Ajay Kumar ^{[1
,2
,4
]}

Kamal, Ahmed ^{[1
,2
,3
]}

机构：

[1] CSIR Indian Inst Chem Technol, Med Chem & Biotechnol Div, Uppal Rd, Hyderabad 500007, Andhra Pradesh, India

[2] Acad Sci Innovat Res AcSIR, Div Chem Sci, New Delhi 110025, India

[3] King Saud Univ, Coll Sci, Dept Chem, Riyadh 11451, Saudi Arabia

[4] CSIR Cent Drug Res Inst, Med & Proc Chem Div, Sect 10,Janakipuram Extens Sitapur Rd, Lucknow 226031, Uttar Pradesh, India

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 6卷 / 07期

关键词：

carbonylation; cross-coupling; green chemistry; heterocycles; oxidation; ONE-POT SYNTHESIS; C-H BONDS; DIMETHYL-SULFOXIDE; DIRECT ARYLATION; SELECTIVE METHOD; ANNULATION; PYRIDINES; CATALYST; ALKYNES; CYCLIZATION;

D O I：

10.1002/ajoc.201700173

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for the oxidative cross-coupling of methylhetarenes with imidazoheterocycles by employing an eco-friendly iodine/DMSO reagent system has been developed. This C(sp(2))-H carbonylation reaction proceeds through an in situ oxidation of a methylhetarene into a formylhetarene followed by an oxidative cross-coupling reaction with an imidazoheterocycle. This method has a wide substrate scope and good functional group tolerance and enables the construction of a large number of carbonylated imidazoheterocycles in very good yields.

引用

页码：890 / 897

页数：8

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