Helicobacter pylori supernatants cause epithelial cytoskeletal disruption that is bacterial strain and epithelial cell line dependent but not toxin VacA dependent

被引：19
作者：
Bebb, JR
Letley, DP
Rhead, JL
Atherton, JC [1 ]
机构：
[1] Univ Nottingham, Univ Nottingham Hosp, Div Gastroenterol, Nottingham NG7 2UH, England
[2] Univ Nottingham, Univ Nottingham Hosp, Inst Infect Immun & Inflammat, Nottingham NG7 2UH, England
来源：
INFECTION AND IMMUNITY | 2003年 / 71卷 / 06期
关键词：
D O I：
10.1128/IAI.71.6.3623-3627.2003
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We show here that Helicobacter pylori broth culture supernatants disrupt the actin cytoskeleton of epithelial cell lines, leading to cell rounding and apoptosis through anoikis. We demonstrate that there are marked quantitative differences between strains and that there are different cell line sensitivities. By constructing VacA null isogenic mutants, we show that the effect is not due to the vacuolating cytotoxin.
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收藏
页码：3623 / 3627
页数：5
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