Total antioxidant capacity of colon in patients with chronic ulcerative colitis

被引:67
作者
Koch, TR
Yuan, LX
Stryker, SJ
Ratliff, P
Telford, GL
Opara, EC
机构
[1] W Virginia Univ, Gastroenterol Sect, LA Johnson VA Med Ctr, Morgantown, WV 26506 USA
[2] Northwestern Univ, Med Ctr, Dept Surg, Chicago, IL USA
[3] Med Coll Wisconsin, Dept Surg, Milwaukee, WI 53226 USA
[4] Duke Univ, Dept Surg, Durham, NC USA
关键词
colon; ulcerative colitis; antioxidant; lipid peroxidation;
D O I
10.1023/A:1005517824877
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
It has been proposed that oxidative stress is involved in the pathophysiology of ulcerative colitis. We have reported the depletion of the nonenzymatic antioxidant, glutathione, in colon from active and inactive ulcerative colitis. The colon contains several biochemically linked antioxidant systems. We hypothesized that diminished total antioxidant capacity in active ulcerative colitis would be associated with increased colonic lipid peroxidation. This study was designed to determine total antioxidant capacity and lipid hydroperoxide levels using colon obtained at surgery from controls (N = 16; 4 females, 12 males; mean age 70 years), and active and inactive ulcerative colitis (N = 15; 3 females, 12 males; mean age 39). Total antioxidant capacity of control colon was higher in muscularis externa compared to the mucosal-submucosal layer (P < 0.05). There were no differences in colonic total antioxidant capacity or lipid hydroperoxide levels comparing control colon to inactive and active ulcerative colitis. The results did not support depletion of tissue total antioxidant capacity by free radicals. Depletion of glutathione in ulcerative colitis may be a specific disorder rather than a secondary defect attributable to global oxidative stress. Nonspecific antioxidant supplements appear unlikely to be beneficial in the treatment of ulcerative colitis.
引用
收藏
页码:1814 / 1819
页数:6
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