Bone mineral density and vitamin K status in children with celiac disease: Is there a relation?

被引:15
作者
Volkan, Burcu [1 ]
Fettah, Ali [2 ]
Islek, Ali [3 ]
Kara, Soner Sertan [2 ]
Kurt, Nezahat [4 ]
Cayir, Atilla [5 ]
机构
[1] Erzurum Reg Training & Res Hosp, Dept Pediat Gastroenterol, Erzurum, Turkey
[2] Erzurum Reg Training & Res Hosp, Dept Pediat, Erzurum, Turkey
[3] Ataturk Univ, Sch Med, Dept Pediat Gastroenterol, Erzurum, Turkey
[4] Ataturk Univ, Sch Med, Dept Biochem, Erzurum, Turkey
[5] Erzurum Reg Training & Res Hosp, Dept Pediat Endocrinol, Erzurum, Turkey
关键词
Celiac disease; bone density; vitamin K; GLUTEN-FREE DIET; PEDIATRIC OFFICIAL POSITIONS; SECONDARY HYPERPARATHYROIDISM; TURKISH CHILDREN; ADOLESCENTS; WOMEN; SUPPLEMENTATION; HEALTH; OSTEOCALCIN; PREVALENCE;
D O I
10.5152/tjg.2018.17451
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background/Aims: To investigate bone mineral density (BMD) in children with celiac disease (CD) and to evaluate the association between vitamin K levels and osteoporosis. Materials and Methods: Children with CD and age-and sex-matched healthy control subjects were prospectively included in the study. BMD was measured, and serum anti-tissue transglutaminase IgA, ferritin, folate, vitamin B12, 25-hydroxy vitamin D and K2, calcium, phosphate, alkaline phosphatase, and parathormone were assayed in all subjects. Results: Overall, 72 patients (mean age 11.69 +/- 3 years, 59.7% female) and 30 healthy subjects (mean age 12.27 +/- 2.12 years, 63.3% female) were enrolled. The mean BMD Z score of the celiac group was significantly lower than that of the control group (-1.23 +/- 1.07 vs. -0.35 +/- 1.04, p=0.001). Vitamin D and K2 values did not differ significantly between the two groups (p>0.05). BMD was positively correlated with vitamin D (r=0.198, p=0.001) and negatively with PTH (r=-0.397, p=0.002). Conclusion: The BMD of celiac patients was lower than that of the control subjects. There was no difference in terms of vitamin D and K2 levels between the two groups. Further studies investigating the level and effect of vitamin K on bone in CD are needed.
引用
收藏
页码:215 / 220
页数:6
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