A fixed partial epithelial-mesenchymal transition (EMT) triggers carcinogenesis, whereas asymmetrical division of hybrid EMT cells drives cancer progression

被引：12
作者：
Denisov, Evgeny V. [1 ,2 ]
Perelmuter, Vladimir M. [1 ]
机构：
[1] Russian Acad Sci, Canc Res Inst, Tomsk Natl Res Med Ctr, 5 Kooperat St, Tomsk 634050, Russia
[2] Tomsk State Univ, Tomsk, Russia
来源：
HEPATOLOGY | 2018年 / 68卷 / 03期
基金：
俄罗斯科学基金会;
关键词：
D O I：
10.1002/hep.29784
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
引用
收藏
页码：807 / 810
页数：4
相关论文
共 8 条
[1]   Numb prevents a complete epithelial-mesenchymal transition by modulating Notch signalling [J].
Bocci, Federico ;
Jolly, Mohit K. ;
Tripathi, Satyendra C. ;
Aguilar, Mitzi ;
Hanash, Samir M. ;
Levine, Herbert ;
Onuchic, Jose N. .
JOURNAL OF THE ROYAL SOCIETY INTERFACE, 2017, 14 (136)
[2]   Tumor evolution: Linear, branching, neutral or punctuated? [J].
Davis, Alexander ;
Gao, Ruli ;
Navin, Nicholas .
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2017, 1867 (02) :151-161
[3]   EMT/MET at the Crossroad of Stemness, Regeneration and Oncogenesis: The Ying-Yang Equilibrium Recapitulated in Cell Spheroids [J].
Forte, Elvira ;
Chimenti, Isotta ;
Rosa, Paolo ;
Angelini, Francesco ;
Pagano, Francesca ;
Calogero, Antonella ;
Giacomello, Alessandro ;
Messina, Elisa .
CANCERS, 2017, 9 (08)
[4]   The H3K9 Methyltransferase G9a Represses E-cadherin and is Associated with Myometrial Invasion in Endometrial Cancer [J].
Hsiao, Sheng-Mou ;
Chen, Min-Wei ;
Chen, Chi-An ;
Chien, Ming-Hsien ;
Hua, Kuo-Tai ;
Hsiao, Michael ;
Kuo, Min-Liang ;
Wei, Lin-Hung .
ANNALS OF SURGICAL ONCOLOGY, 2015, 22 :S1556-S1565
[5]   ZEB1 drives epithelial-to-mesenchymal transition in lung cancer [J].
Larsen, Jill E. ;
Nathan, Vaishnavi ;
Osborne, Jihan K. ;
Farrow, Rebecca K. ;
Deb, Dhruba ;
Sullivan, James P. ;
Dospoy, Patrick D. ;
Augustyn, Alexander ;
Hight, Suzie K. ;
Sato, Mitsuo ;
Girard, Luc ;
Behrens, Carmen ;
Wistuba, Ignacio I. ;
Gazdar, Adi F. ;
Hayward, Nicholas K. ;
Minna, John D. .
JOURNAL OF CLINICAL INVESTIGATION, 2016, 126 (09) :3219-3235
[6]   Stochastic phenotype switching leads to intratumor heterogeneity in human liver cancer [J].
Matak, Andrija ;
Lahiri, Pooja ;
Ford, Ethan ;
Pabst, Daniela ;
Kashofer, Karl ;
Stellas, Dimitris ;
Thanos, Dimitris ;
Zatloukal, Kurt .
HEPATOLOGY, 2018, 68 (03) :933-948
[7]   Mechanisms of malignant progression [J].
Weinberg, Robert A. .
CARCINOGENESIS, 2008, 29 (06) :1092-1095
[8]   The epithelial to mesenchymal transition (EMT) produces colorectal cancer subpopulations with strikingly different mutation profiles [J].
Yang, Mingli ;
Schell, Michael J. ;
Lee, Norman H. ;
Yeatman, Timothy J. .
CANCER RESEARCH, 2015, 75
1