Diabetic Neuropathy

被引:103
作者
Zakin, Elina [1 ]
Abrams, Rory [2 ]
Simpson, David M. [2 ]
机构
[1] NYU Langone Sch Med, Dept Neurol, Div Neuromuscular Med, 222 East 41st St, New York, NY 10017 USA
[2] Icahn Sch Med Mt Sinai, Div Neuromuscular Med, Dept Neurol, New York, NY 10029 USA
关键词
diabetic neuropathy; distal symmetric polyneuropathy; neuropathic pain; QUALITY-OF-LIFE; PERIPHERAL NEUROPATHY; DOUBLE-BLIND; POSTHERPETIC NEURALGIA; RANDOMIZED-WITHDRAWAL; DIAGNOSTIC-CRITERIA; CHARCOT FOOT; PAIN; PLACEBO; LAMOTRIGINE;
D O I
10.1055/s-0039-1688978
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Diabetes mellitus is becoming increasingly common worldwide. As this occurs, there will be an increase in the prevalence of known comorbidities from this disorder of glucose metabolism. One of the most disabling adverse comorbidities is diabetic neuropathy. The most common neuropathic manifestation is distal symmetric polyneuropathy, which can lead to sensory disturbances, including diminished protective sense, making patients prone to foot injuries. However, focal, multifocal, and autonomic neuropathies are also common. Diabetic nerve pain and Charcot osteoarthropathy are advanced neuropathic conditions that portend a severe deterioration in quality of life. To combat these symptoms, along with glycemic control and establishment of health care systems to educate and support patients with the complexities of diabetes, there are pharmacologic remedies to ameliorate the neurologic symptoms. Several guidelines and review boards generally recommend the use of tricyclic antidepressants, serotonin/norepinephrine-reuptake inhibitors, alpha-2-delta ligands, and anticonvulsants as medications to improve painful diabetic neuropathy and quality of life.
引用
收藏
页码:560 / 569
页数:10
相关论文
共 81 条
[31]   Risk factors for neuropathic pain in diabetes mellitus [J].
Hebert, Harry L. ;
Veluchamy, Abirami ;
Torrance, Nicola ;
Smith, Blair H. .
PAIN, 2017, 158 (04) :560-568
[32]   Duloxetine in Painful Diabetic Neuropathy: A Systematic Review [J].
Hossain, Sultana Mehbuba ;
Hussain, Sultana Monira ;
Ekram, A. R. M. S. .
CLINICAL JOURNAL OF PAIN, 2016, 32 (11) :1005-1010
[33]   Diabetic Peripheral Neuropathy: Epidemiology, Diagnosis, and Pharmacotherapy [J].
Iqbal, Zohaib ;
Azmi, Shazli ;
Yadav, Rahul ;
Ferdousi, Maryam ;
Kumar, Mohit ;
Cuthbertson, Daniel J. ;
Lim, Jonathan ;
Malik, Rayaz A. ;
Alam, Uazman .
CLINICAL THERAPEUTICS, 2018, 40 (06) :828-849
[34]   Prevalence of and Risk Factors for Diabetic Peripheral Neuropathy in Youth With Type 1 and Type 2 Diabetes: SEARCH for Diabetes in Youth Study [J].
Jaiswal, Mamta ;
Divers, Jasmin ;
Dabelea, Dana ;
Isom, Scott ;
Bell, Ronny A. ;
Martin, Catherine L. ;
Pettitt, David J. ;
Saydah, Sharon ;
Pihoker, Catherine ;
Standiford, Debra A. ;
Dolan, Lawrence M. ;
Marcovina, Santica ;
Linder, Barbara ;
Liese, Angela D. ;
Pop-Busui, Rodica ;
Feldman, Eva L. .
DIABETES CARE, 2017, 40 (09) :1226-1232
[35]   Burning through the pain: treatments for diabetic neuropathy [J].
Javed, S. ;
Alam, U. ;
Malik, R. A. .
DIABETES OBESITY & METABOLISM, 2015, 17 (12) :1115-1125
[36]   Charcot foot syndrome [J].
Jeffcoate, W. J. .
DIABETIC MEDICINE, 2015, 32 (06) :760-770
[37]   Randomized double-blind study comparing the efficacy and safety of lamotrigine and amitriptyline in painful diabetic neuropathy [J].
Jose, V. M. ;
Bhansali, A. ;
Hota, D. ;
Pandhi, P. .
DIABETIC MEDICINE, 2007, 24 (04) :377-383
[38]   Pathways in the Diagnosis and Management of Diabetic Polyneuropathy [J].
Kaku, Michelle ;
Vinik, Aaron ;
Simpson, David M. .
CURRENT DIABETES REPORTS, 2015, 15 (06) :1-16
[39]   HIV neuropathy [J].
Kaku, Michelle ;
Simpson, David M. .
CURRENT OPINION IN HIV AND AIDS, 2014, 9 (06) :521-526
[40]  
Kaltsas G., 2000, ENDOTEXT