Amide-directed arylation of sp3 C-H bonds using Pd(II) and Pd(0) catalysts

被引：41

作者：

Wasa, Masayuki ^{[1
]}

Yu, Jin-Quan ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

TETRAHEDRON | 2010年 / 66卷 / 26期

基金：

美国国家卫生研究院;

关键词：

Amide; Palladium; Arylation; sp(3) C-H activation; ANILIDE ORTHO-ARYLATION; COUPLING REACTIONS; OXIDATIVE FUNCTIONALIZATION; REDUCTIVE ELIMINATION; ARYL; ACTIVATION; ACIDS; SP(2); ALKYLATION; REGIOSELECTIVITY;

D O I：

10.1016/j.tet.2010.03.111

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Protocols to effect beta-arylation of sp(3) C-H bonds via Pd(II)/(IV) and Pd(0)/(II) catalytic cycles have been achieved using a newly developed monodentate CONHC6F5 directing group. These reactions provide an unprecedented means to functionalize sp(3) C-H bonds in aliphatic carboxylic acid-derived substrates. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：4811 / 4815

页数：5

共 72 条

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