Coronary calcium scoring potential of large field-of-view spectral photon-counting CT: a phantom study

被引:43
|
作者
van der Werf, Niels R. [1 ,2 ]
Si-Mohamed, S. [3 ,4 ]
Rodesch, P. A. [3 ,4 ]
van Hamersvelt, R. W. [1 ]
Greuter, M. J. W. [5 ]
Boccalini, S. [3 ,4 ]
Greffier, J. [6 ]
Leiner, T. [1 ]
Boussel, L. [3 ,4 ]
Willemink, M. J. [7 ]
Douek, P. [3 ,4 ]
机构
[1] Univ Med Ctr Utrecht, Dept Radiol, Utrecht, Netherlands
[2] Erasmus MC, Dept Radiol & Nucl Med, Rotterdam, Netherlands
[3] Hosp Civils Lyon, Louis Pradel Cardiol Hosp, Lyon, France
[4] Univ Claude Bernard Lyon 1, Univ Lyon, INSA Lyon, UJM St Etienne,CNRS,Inserm,CREATIS UMR 5220,U1206, Lyon, France
[5] Univ Groningen, Univ Med Ctr Groningen, Dept Radiol, Groningen, Netherlands
[6] Univ Montpellier, Dept Med Imaging, Med Imaging Grp, CHU Nimes, F-2415 Nimes, EA, France
[7] Stanford Univ, Sch Med, Dept Radiol, Stanford, CA 94305 USA
关键词
X-ray computed tomography; Calcium; Coronary vessels; Imaging phantoms; ARTERY CALCIUM; PULSE PILEUP; QUANTIFICATION; DISEASE; SYSTEM; RISK;
D O I
10.1007/s00330-021-08152-w
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Objective The aim of the current study was, first, to assess the coronary artery calcium (CAC) scoring potential of spectral photon-counting CT (SPCCT) in comparison with computed tomography (CT) for routine clinical protocols. Second, improved CAC detection and quantification at reduced slice thickness were assessed. Methods Raw data was acquired and reconstructed with several combinations of reduced slice thickness and increasing strengths of iterative reconstruction (IR) for both CT systems with routine clinical CAC protocols for CT. Two CAC-containing cylindrical inserts, consisting of CAC of different densities and sizes, were placed in an anthropomorphic phantom. A specific CAC was detectable when 3 or more connected voxels exceeded the CAC scoring threshold of 130 Hounsfield units (HU). For all reconstructions, total CAC detectability was compared between both CT systems. Significant differences in CAC quantification (Agatston and volume scores) were assessed with Mann-Whitney U tests. Furthermore, volume scores were compared with the known CAC physical. Results CAC scores for routine clinical protocols were comparable between SPCCT and CT. SPCCT showed 34% and 4% higher detectability of CAC for the small and large phantom, respectively. At reduced slice thickness, CAC detection increased by 142% and 169% for CT and SPCCT, respectively. In comparison with CT, volume scores from SPCCT were more comparable with the physical volume of the CAC. Conclusion CAC scores using routine clinical protocols are comparable between conventional CT and SPCCT. The increased spatial resolution of SPCCT allows for increased detectability and more accurate CAC volume estimation.
引用
收藏
页码:152 / 162
页数:11
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