Development of a spray-type adhesion barrier

被引：4
作者：
Chino, Naotaka [1 ]
Ishihara, Hiroyuki [1 ]
Niimi, Taishi [1 ]
Kai, Miho [1 ]
Kawanishi, Tetsuro [1 ]
机构：
[1] Terumo Co Ltd, R&D Ctr, 1500 Inokuchi Nakai Machi, Nakai, Kanagawa, Japan
来源：
POLYMER JOURNAL | 2020年 / 52卷 / 05期
关键词：
POSTOPERATIVE ABDOMINAL ADHESIONS; HOSPITAL READMISSIONS; DOUBLE-BLIND; PREVENTION; SURGERY; ICODEXTRIN; SEPRAFILM; MULTICENTER; LAPAROSCOPY; REDUCTION;
D O I：
10.1038/s41428-020-0306-0
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
We developed a novel spray-type dextrin hydrogel-based adhesion barrier designed to create a site-specific barrier on a target. Our novel hydrogel is composed of Powder A, which mainly contains N-hydroxysuccinimide-modified carboxymethyl dextrin and trehalose as a stabilizing agent, and Powder B, which is composed of sodium carbonate and sodium hydrogen carbonate. Here, we describe the product specifications of the hydrogel and results of in vivo performance evaluations and clinical studies to demonstrate its efficacy and safety. A novel spray-type dextrin hydrogel-based adhesion barrier is composed of N-hydroxysuccinimide-modified carboxymethyl dextrin that is biodegradable polymer material. The performance evaluation of a spray-type adhesion barrier in porcine laparoscopic model was showed significantly lowered adhesion rate than in the control group (p < 0.001), and no hydrogel residue was observed macroscopically at the spraying site 28 +/- 1 days after surgery.
引用
收藏
页码：473 / 479
页数：7
相关论文
共 29 条
[1]   Fluid and pharmacological agents for adhesion prevention after gynaecological surgery [J].
Ahmad, Gaity ;
Mackie, Fiona L. ;
Iles, David A. ;
O'Flynn, Helena ;
Dias, Sofia ;
Metwally, Mostafa ;
Watson, Andrew .
COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2014, (07)
[2]   Laparoscopy in Gynecologic Surgery: Adhesion Development, Prevention, and Use of Adjunctive Therapies [J].
Awonuga, Awoniyi O. ;
Saed, Ghassan M. ;
Diamond, Michael P. .
CLINICAL OBSTETRICS AND GYNECOLOGY, 2009, 52 (03) :412-422
[3]   Adept (icodextrin 4% solution) reduces adhesions after laparoscopic surgery for adhesiolysis: a double-blind, randomized, controlled study [J].
Brown, Colin B. ;
Luciano, Anthony A. ;
Martin, Dan ;
Peers, Elizabeth ;
Scrimgeour, Alison ;
diZerega, Gere S. .
FERTILITY AND STERILITY, 2007, 88 (05) :1413-1426
[4]   How to avoid risks for patients in minimal access trials: Avoiding complications in clinical first-in-human studies by example of the ADBEE study [J].
Cezar, Cristina ;
Korell, Matthias ;
Tchartchian, Garri ;
Ziegler, Nicole ;
Senshu, Kazuhisa ;
Herrmann, Anja ;
Larbig, Angelika ;
De Wilde, Rudy Leon .
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY, 2016, 35 :84-96
[5]   Long term follow-up concerning safety and efficacy of novel adhesion prophylactic agent for laparoscopic myomectomy in the prospective randomized ADBEE study [J].
Cezar, Cristina ;
Tchartchian, Garri ;
Korell, Matthias ;
Ziegler, Nicole ;
Senshu, Kazuhisa ;
De Wilde, Maya Sophie ;
Herrmann, Anja ;
Larbig, Angelika ;
De Wilde, Rudy Leon .
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY, 2016, 35 :97-112
[6]   Modified Novel Technique for Improving the Success Rate of Applying Seprafilm by Using Laparoscopy [J].
Chuang, Yi-chen ;
Lu, Hsin-Fen ;
Peng, Fu-Shiang ;
Ting, Wan-Hua Stella ;
Tu, Fung-Chao ;
Chen, Ming-jer ;
Kan, Yuen-Yee .
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY, 2014, 21 (05) :787-790
[7]   Postoperative abdominal adhesions and their prevention in gynaecological surgery. Expert consensus position. Part 2-steps to reduce adhesions [J].
DeWilde, Rudy Leon ;
Trew, Geoffrey .
GYNECOLOGICAL SURGERY, 2007, 4 (04) :243-253
[8]   Postoperative abdominal adhesions and their prevention in gynaecological surgery. Expert consensus position [J].
DeWilde, Rudy Leon ;
Trew, Geoffrey .
GYNECOLOGICAL SURGERY, 2007, 4 (03) :161-168
[9]  
DIZEREGA GS, 1994, FERTIL STERIL, V61, P219
[10]  
El-Mowafi Diaa M, 2003, Surg Technol Int, V11, P222
123