Homocysteine, Vitamins B6 and Folic Acid in Experimental Models of Myocardial Infarction and Heart Failure-How Strong Is That Link?

被引：48

作者：

Bajic, Zorislava ^{[1
]}

Sobot, Tanja ^{[1
]}

Skrbic, Ranko ^{[2
]}

Stojiljkovic, Milos P. ^{[2
]}

Ponorac, Nenad ^{[1
]}

Matavulj, Amela ^{[1
]}

Djuric, Dragan M. ^{[3
]}

机构：

[1] Univ Banja Luka, Dept Physiol, Fac Med, Banja Luka 78000, Bosnia & Herceg

[2] Univ Banja Luka, Dept Pharmacol Toxicol & Clin Pharmacol, Fac Med, Banja Luka 78000, Bosnia & Herceg

[3] Univ Belgrade, Inst Med Physiol Richard Burian, Fac Med, Belgrade 11000, Serbia

来源：

BIOMOLECULES | 2022年 / 12卷 / 04期

关键词：

homocysteine; vitamin B6; folic acid; myocardial infarction; heart failure; experimental models; ISCHEMIA-REPERFUSION INJURY; ENDOGENOUS HYDROGEN-SULFIDE; N-ACETYLCYSTEINE TREATMENT; C-REACTIVE PROTEIN; NITRIC-OXIDE; OXIDATIVE STRESS; CARBON-MONOXIDE; ENDOTHELIAL DYSFUNCTION; GLUTATHIONE-PEROXIDASE; CARDIAC-FUNCTION;

D O I：

10.3390/biom12040536

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cardiovascular diseases are the leading cause of death and the main cause of disability. In the last decade, homocysteine has been found to be a risk factor or a marker for cardiovascular diseases, including myocardial infarction (MI) and heart failure (HF). There are indications that vitamin B6 plays a significant role in the process of transsulfuration in homocysteine metabolism, specifically, in a part of the reaction in which homocysteine transfers a sulfhydryl group to serine to form alpha-ketobutyrate and cysteine. Therefore, an elevated homocysteine concentration (hyperhomocysteinemia) could be a consequence of vitamin B6 and/or folate deficiency. Hyperhomocysteinemia in turn could damage the endothelium and the blood vessel wall and induce worsening of atherosclerotic process, having a negative impact on the mechanisms underlying MI and HF, such as oxidative stress, inflammation, and altered function of gasotransmitters. Given the importance of the vitamin B6 in homocysteine metabolism, in this paper, we review its role in reducing oxidative stress and inflammation, influencing the functions of gasotransmitters, and improving vasodilatation and coronary flow in animal models of MI and HF.

引用

页数：27

共 218 条

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