Altered expression of TGF-β1 and TGF-βR2 in tissue samples compared to blood is associated with food habits and survival in esophageal squamous cell carcinoma

被引：4

作者：

Talukdar, Jayasree ^{[1
,2
]}

Kataki, Kangkana ^{[1
]}

Ali, Eyashin ^{[1
,2
]}

Choudhury, Bikash Narayan ^{[2
]}

Baruah, Munindra Narayan ^{[3
]}

Bhattacharyya, Mallika ^{[2
]}

Bhattacharjee, Sahana ^{[4
]}

Medhi, Subhash ^{[1
]}

机构：

[1] Gauhati Univ, Dept Bioengn & Technol, Lab Mol Virol & Oncol, GUIST, Gauhati, Assam, India

[2] Gauhati Med Coll Hosp, Dept Gastroenterol, Gauhati, India

[3] North East Canc Hosp & Res Inst, Dept Head & Neck Oncol, Jorabat, India

[4] Gauhati Univ, Dept Stat, Gauhati, India

来源：

CURRENT PROBLEMS IN CANCER | 2021年 / 45卷 / 01期

关键词：

TGF-beta; 1; TGF-beta R2; Esophageal squamous cell carcinoma; TRANSFORMING-GROWTH-FACTOR; FACTOR-BETA; RISK-FACTORS; CANCER; TOBACCO; GROWTH-FACTOR-BETA-1; RECEPTORS; OVEREXPRESSION; SHANGHAI; ALCOHOL;

D O I：

10.1016/j.currproblcancer.2020.100617

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In the transforming growth factor beta (TGF-beta) signaling pathway, TGF-beta 1 and TGF-beta receptor 2 (TGF-beta R2) are essential regulatory components which play an important role in different type of cancer. Expressions of TGF-beta 1 and TGF-beta R2 were done by real-time qPCR in both biopsy and blood samples collected from esophageal squamous cell carcinoma (ESCC) patients (n = 76). The expression profiles were correlated with different lifestyle factors and clinicopathological parameters. Kaplan-Meier survival analysis and Cox regression analysis were performed to estimate survival and hazard outcomes of different parameters. TGF-beta 1 showed upregulation in 91% tissue samples (2.84 +/- 1.34*) and 55% blood samples (2.43 +/- 1.24*) whereas expression of TGF-beta R2 showed downregulation in 89% tissue samples (0.27 +/- 0.23*) and 75% blood samples (0.30 +/- 0.26*). Among all the parameters, TGF-beta 1 expression is significant with histopathology grade, consumption of betel nut and smoked food whereas TGF-beta R2 expression is significant only with dysphagia grade in both blood and tissue samples and while analyzing both male and female patients separately. Consuming alcohol and hot food, difference in tumor stage and metastasis were found to have statistically significant (P < 0.05) impact on survival and mortality of male patients while consuming hot food, tobacco, metastasis and TGF-beta R2 expression in tissue level were found to associate with survival and mortality of female patients. Expression of both TGF-beta 1 and TGF-beta R2 in tissue samples may be prospective biomarkers for screening of ESCC among the Northeast population. Survival outcomes and hazard analysis supports the importance of some clinicopathological and lifestyle factors on ESCC development, whereas expression study depicts association of change in expression of the studied genes in ESCC patients. *Mean fold change. (C) 2020 Elsevier Inc. All rights reserved.

引用

页数：20

共 39 条

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