Clinical Outcomes of Patients With pT1-T2N0 Oral Tongue Squamous Cell Carcinoma

被引：4

作者：

Wilson, Jessica M. ^{[1
]}

Lumley, Catherine ^{[2
]}

Tan, Xianming ^{[3
]}

Shen, Colette ^{[1
]}

Coniglio, Andrew ^{[2
]}

Weissler, Mark ^{[2
]}

Yarbrough, Wendell G. ^{[2
]}

Hackman, Trevor ^{[2
]}

Blumberg, Jeffrey ^{[2
]}

Zanation, Adam ^{[2
]}

Thorp, Brian ^{[2
]}

Patel, Samip N. ^{[2
]}

Chera, Bhishamjit S. ^{[1
]}

机构：

[1] Univ N Carolina, Dept Radiat Oncol, Chapel Hill, NC 27515 USA

[2] Univ N Carolina, Sch Med, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC 27515 USA

[3] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27515 USA

来源：

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS | 2021年 / 44卷 / 05期

关键词：

cancer of mouth; oral cancer; cancer of tongue; tongue cancer; cancer of the tongue; NECK DISSECTION; LOCOREGIONAL RECURRENCE; WORST PATTERN; CANCER; METASTASIS; PREDICTORS; SURVIVAL; INVASION; DEPTH;

D O I：

10.1097/COC.0000000000000806

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective: The objective of this study was to evaluate the clinical outcomes in a cohort of patients with early-stage oral tongue squamous cell carcinoma (OTSCC). Materials and Methods: We conducted a retrospective analysis of patients with pT1-T2N0 (American Joint Committee on Cancer [AJCC] seventh edition) OTSCC treated from 2000 to 2018. Two-year actuarial rates of local regional control, cancer-specific survival, and overall survival were calculated for the entire cohort and patients with/without adjuvant radiation. Results: Ninety-six patients met the criteria with a median follow-up of 4 years; 14 had adjuvant radiation, while 82 had surgery alone. Two-year local regional control was 82.7% (75.4% to 90.8%) for the entire cohort, 84.9% (77.8% to 93.2%) for surgery only, and 70.7% (50.2% to 99.6%) for patients with adjuvant radiation. Two-year progression-free survival was 82.7% (75.3% to 90.8%). Of the 20 patients with recurrence, 11 (55%) were successfully salvaged. Conclusion: Local regional recurrence remains modest in early-stage OTSCC, but salvage is possible with high survival rates.

引用

页码：200 / 205

页数：6

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