Mutasynthesis - uniting chemistry and genetics for drug discovery

被引：67

作者：

Weissman, Kira J. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England

来源：

TRENDS IN BIOTECHNOLOGY | 2007年 / 25卷 / 04期

关键词：

D O I：

10.1016/j.tibtech.2007.02.004

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Mutasynthesis couples the power of chemical synthesis with molecular biology to generate derivatives of medicinally valuable, natural products. Recently, this technique has been exploited by Cambridge-based biotech company Biotica Technology Ltd, and their collaborators, to generate promising new variants of the polyketide anti-cancer compounds rapamycin and borrelidin.

引用

页码：139 / 142

页数：4

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