A new HLA-DRB allele (DRB1*15014) identified in a Caucasian individual

被引：0
|
作者：
Czachurski, D [1 ]
Opelz, G [1 ]
Mytilineos, J [1 ]
机构：
[1] Heidelberg Univ, Inst Immunol, Dept Transplantat Immunol, D-69120 Heidelberg, Germany
来源：
HUMAN IMMUNOLOGY | 2003年 / 64卷 / 02期
关键词：
HLA-DRB1; PCR-SSP; sequence-based typing; DRB1*15014;
D O I：
10.1016/S0198-8859(02)00779-6
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Polymerase chain reaction with sequence specific primers subtyping of a DRB1*15 allele in a male 11-year-old German Caucasian and his father revealed a reaction pattern that did not agree with any known specificity, thus suggesting the existence of a novel allele. Sequence-based typing after allelic separation revealed the new allele human leukocyte antigen (HLA)-DRB1*15014. The sequence pattern of HLA-DRB1*15014 might have been generated as a result of two independent recombinations, most likely over several generations. (C) American Society for Histocompatibility and Immunogenetics, 2003. Published by Elsevier Science Inc.
引用
收藏
页码：310 / 313
页数：4
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