Promoter methylation and the detection of breast cancer

被引:56
作者
Brooks, Jennifer [1 ]
Cairns, Paul [2 ]
Zeleniuch-Jacquotte, Anne [1 ]
机构
[1] NYU, Dept Environm Med, Sch Med, Div Epidemiol, New York, NY 10016 USA
[2] Fox Chase Canc Ctr, Dept Surg Oncol, Philadelphia, PA 19111 USA
关键词
Breast neoplasms; Early detection of cancer; DNA methylation; INVASIVE LOBULAR CARCINOMA; POLYMERASE-CHAIN-REACTION; DNA METHYLATION; MULTIPLE GENES; SERUM DNA; ABERRANT METHYLATION; DIAGNOSTIC-ACCURACY; RECEPTOR STATUS; BLADDER-CANCER; LUNG-CANCER;
D O I
10.1007/s10552-009-9415-y
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Mammographic screening has been shown to reduce breast cancer mortality in women over the age of 50 years, and to a lesser extent in younger women. The sensitivity of mammography, however, is reduced in some groups of women. There remains a need for a minimally invasive, cost-effective procedure that could be used along side mammography to improve screening sensitivity. Silencing of tumor suppressor genes through promoter hypermethylation is known to be a frequent and early event in carcinogenesis. Further, changes in methylation patterns observed in tumors are also detectable in the circulation of women with breast cancer. This makes these alterations candidate markers for early tumor detection. In this paper, we review the current literature on promoter hypermethylation changes and breast cancer and discuss issues that remain to be addressed in order for the potential of these markers to augment the sensitivity of screening mammography. In general, studies in well-defined populations, including appropriate controls and larger numbers are needed. Further, focus on the optimization of methods of methylation detection in small amounts of DNA is needed.
引用
收藏
页码:1539 / 1550
页数:12
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