Gamma radiation synthesis of a novel amphiphilic terpolymer hydrogel pH-responsive based chitosan for colon cancer drug delivery

Particularly, chitosan (Cs) loaded with drug cannot pass through the colonic region, often leading in the bursting drug release in the stomach due to its solubility in gastric contents. The novelty of the current article is to solve this limitation by performing gamma irradiation cross-linking of Cs with two anionic polymers of (acrylic acid)-co-(2-acrylamido-2-methylpropane-sulfonic acid) (AAc/AMPS) to give amphiphilic hydrogel. The shifted in the characteristic FTIR peaks of Cs in the (Cs/AAc/AMPS) confirm the exits of inter-molecular interactions that make Cs and (AAc/AMPS) are miscible. Swelling experiments under different pH indicated that the (Cs/AAc/AMPS) hydrogels were significantly sensitive to pH change. The results give the possibility to use the obtained (Cs/AAc/ AMPS) hydrogel on drug delivery system. The in vitro Fluorouracil (5-FU) releasing from (Cs/AAc/AMPS) matrix was examined under the influence of pH1 and pH7.The results confirmed the hydrogels capability to release 96 % of 5-FU drug at pH 7 after 7 h.