Synthesis of O-prenylated and O-geranylated derivatives of 5-benzylidene2,4-thiazolidinediones and evaluation of their free radical scavenging activity as well as effect on some phase II antioxidant/detoxifying enzymes

被引：51
作者：
Hossain, Sk. Ugir [1 ]
Bhattacharya, Sudin [1 ]
机构：
[1] Chittaranjan Natl Canc Inst, Dept Canc Chemoprevent, Kolkata 700026, W Bengal, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 05期
关键词：
2,4-thiazolidinediones; radical scavenger; detoxifying enzyme; mice;
D O I：
10.1016/j.bmcl.2006.12.040
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of 5-arylidene-2,4-thiazolidinediones and its geranyloxy or prenyloxy derivative were synthesized and studied for their radical scavenging activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Their comparable scavenging activities were expressed as IC50 value. Compounds 2c, 2d, 4d, and 6a showed appreciable radical scavenging activities. The vanillin based thiazolidinedione compound 2c displayed highest activity comparable to that of alpha-tocopherol. But in vivo, compound 6a showed better results in inducing phase II detoxifying/antioxidative enzyme. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1149 / 1154
页数：6
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