How to treat paracetamol overdose and when to do it

被引：9

作者：

Antoine, Daniel J. ^{[1
]}

Dear, James W. ^{[2
]}

机构：

[1] Univ Liverpool, Inst Translat Med, Dept Mol & Clin Pharmacol, MRC Ctr Drug Safety Sci, Liverpool L69 3BX, Merseyside, England

[2] Univ Edinburgh, Univ BHF Ctr Cardiovasc Sci, Queens Med Res Inst, Dept Pharmacol Toxicol & Therapeut, Edinburgh, Midlothian, Scotland

来源：

EXPERT REVIEW OF CLINICAL PHARMACOLOGY | 2016年 / 9卷 / 05期

基金：

英国医学研究理事会;

关键词：

RANDOMIZED CONTROLLED-TRIAL; N-ACETYLCYSTEINE; ACETAMINOPHEN; HEPATOTOXICITY; BIOMARKERS; PROGNOSIS; INJURY; SERUM;

D O I：

10.1586/17512433.2016.1154786

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：633 / 635

页数：3

共 22 条

[1] Acetaminophen Adducts Detected in Serum of Pediatric Patients With Acute Liver Failure [J].

Alonso, Estella M. ;

James, Laura P. ;

Zhang, Song ;

Squires, Robert H. .

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2015, 61 (01) :102-107

[2] Circulating Kidney Injury Molecule 1 Predicts Prognosis and Poor Outcome in Patients With Acetaminophen-Induced Liver Injury [J].

Antoine, Daniel J. ;

Sabbisetti, Venkata S. ;

Francis, Ben ;

Jorgensen, Andrea L. ;

Craig, Darren G. N. ;

Simpson, Kenneth J. ;

Bonventre, Joseph V. ;

Park, B. Kevin ;

Dear, James W. .

HEPATOLOGY, 2015, 62 (02) :591-599

[3] Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital [J].

Antoine, Daniel J. ;

Dear, James W. ;

Lewis, Philip Starkey ;

Platt, Vivien ;

Coyle, Judy ;

Masson, Moyra ;

Thanacoody, Ruben H. ;

Gray, Alasdair J. ;

Webb, David J. ;

Moggs, Jonathan G. ;

Bateman, D. Nicholas ;

Goldring, Christopher E. ;

Park, B. Kevin .

HEPATOLOGY, 2013, 58 (02) :777-787

[4] RETRACTED: Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity (Publication with Expression of Concern. See vol. 73, pg. 1297, 2020) (Publication with Expression of Concern. See vol. 69, pg. 1402, 2018) (Retracted article. See vol. 73, pg. 1297, 2020) [J].

Antoine, Daniel J. ;

Jenkins, Rosalind E. ;

Dear, James W. ;

Williams, Dominic P. ;

McGill, Mitchell R. ;

Sharpe, Matthew R. ;

Craig, Darren G. ;

Simpson, Kenneth J. ;

Jaeschke, Hartmut ;

Park, B. Kevin .

JOURNAL OF HEPATOLOGY, 2012, 56 (05) :1070-1079

[5] Effect of the UK's revised paracetamol poisoning management guidelines on admissions, adverse reactions and costs of treatment [J].

Bateman, D. Nicholas ;

Carroll, Robert ;

Pettie, Janice ;

Yamamoto, Takahiro ;

Elamin, Muhammad E. M. O. ;

Peart, Lucy ;

Dow, Margaret ;

Coyle, Judy ;

Cranfield, Kristina R. ;

Hook, Christopher ;

Sandilands, Euan A. ;

Veiraiah, Aravindan ;

Webb, David ;

Gray, Alasdair ;

Dargan, Paul I. ;

Wood, David M. ;

Thomas, Simon H. L. ;

Dear, James W. ;

Eddleston, Michael .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2014, 78 (03) :610-618

[6] Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial [J].

Bateman, D. Nicholas ;

Dear, James W. ;

Thanacoody, H. K. Ruben ;

Thomas, Simon H. L. ;

Eddleston, Michael ;

Sandilands, Euan A. ;

Coyle, Judy ;

Cooper, Jamie G. ;

Rodriguez, Aryelly ;

Butcher, Isabella ;

Lewis, Steff C. ;

Vliegenthart, A. D. Bastiaan ;

Veiraiah, Aravindan ;

Webb, David J. ;

Gray, Alasdair .

LANCET, 2014, 383 (9918) :697-704

[7] Evidence for the changing regimens of acetylcysteine [J].

Chiew, Angela L. ;

Isbister, Geoffrey K. ;

Duffull, Stephen B. ;

Buckley, Nicholas A. .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2016, 81 (03) :471-481

[8] Where are we now with paracetamol? [J].

Dear, James W. ;

Antoine, Daniel J. ;

Park, B. Kevin .

BMJ-BRITISH MEDICAL JOURNAL, 2015, 351

[9] Stratification of paracetamol overdose patients using new toxicity biomarkers: current candidates and future challenges [J].

Dear, James W. ;

Antoine, Daniel J. .

EXPERT REVIEW OF CLINICAL PHARMACOLOGY, 2014, 7 (02) :181-189

[10] Treating acetaminophen overdose: thresholds, costs and uncertainties [J].

Gosselin, S. ;

Hoffman, R. S. ;

Juurlink, D. N. ;

Whyte, I. ;

Yarema, M. ;

Caro, J. .

CLINICAL TOXICOLOGY, 2013, 51 (03) :130-133

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